Edited by

  • David Cheresh, The Scripps Research Institute, La Jolla, CA, USA

An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
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Biochemists and researchers in related life science fields.


Book information

  • Published: August 2007
  • ISBN: 978-0-12-373924-7

Table of Contents

Chapter 1: Quantitative Measurements of Integrin-Mediated Adhesion to Extracellular MatrixChapter 2: Investigating Integrin regulation and signaling events in three dimensional systemsChapter 3: Integrins in Cell MigrationChapter 4: Imtegrin Cytoskeletal InteracionsChapter 5: Cell Survival in a 3D MatrixChapter 6: Platelet Integrin Adhesive Functions and SignalingChapter 7: Development of Monoclonal Antibodies to Integrin ReceptorsChapter 8: Cell adhesion, cellular tension, and cell cycle controlChapter 9: Analysis of Integrin Signaling by Fluorescence Resonance Energy TransferChapter 10: Studies on integrins in the nervous systemChapter 11: Methods for identifying novel integrin ligandsChapter 12: Analysis of integrin functions in peri-implantation embryos, hematopoietic system and skinChapter 13: Identification and molecular characterization of multiple phenotypes in integrin knockout miceChapter 14: Purification, Analysis and Crystal Structure of IntegrinsChapter 15: Electron Microscopy of IntegrinsChapter 16: Intravital Imaging and Cell InvasionChapter 17: Using Xenopus Embryos to Investigate Integrin FunctionChapter 18: Methods to Study Lymphatic Vessel IntegrinsChapter 19: Analysis of Integrin Signaling in Genetically Engineered Mouse Models of Mammary Tumor ProgressionChapter 20: Design and Chemical Synthesis of Integrin Ligands