Baculoviruses are perhaps unique among viruses in the breadth of their biotechnological applications: these insect specific viruses are used not only for insect pest management purposes, but also as laboratory research tools for production of recombinant proteins and for protein display, and as potential vectors for human gene therapy. In addition to highlighting recent advances, this volume provides a comprehensive review of the biotechnological applications of these and other insect viruses in both the academic and private sectors.View full description
Researchers and postgraduates within academia and industry working in virology, entomology, biotechnology, insect pest management and biological control, human gene therapy, vaccinology, plant pathology, drug discovery, and genetics
- Published: September 2006
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-039868-3
Table of ContentsInsect Viruses as Laboratory Research ToolsMilestones Leading to the Genetic Engineering of Baculoviruses as Expression Vector Systems and Viral PesticidesPolydnavirus genes that enhance the baculovirus expression vector systemBaculovirus Display: A Multi-Functional Technology for Gene Delivery and Eukaryotic Library DevelopmentStably transformed insect cell lines: Tools for expression of secreted and membrane-anchored proteins and high throughput screening platforms for drug and insecticide discoveryApplications to Human and Animal HealthProtein N-glycosylation in the baculovirus-insect cell expression system and efforts to engineer insect cells to produce “mammalianized” recombinant glycoproteinsVaccines for viral and parasitic diseases produced with baculovirus vectorsBaculoviruses and Mammalian Cell-Based Assays for Drug ScreeningBaculovirus Vectors for Gene TherapyInsect Pest ManagementGenetically Modified Baculoviruses: A Historical Overview and Future OutlookDensoviruses for Control and Genetic Manipulation of MosquitoesPotential Uses of Cys-Motif and Other Polydnavirus Genes in BiotechnologyVirus-derived genes for insect resistant transgenic plantsSmall RNA Viruses of Insects: Expression in Plants and RNA Silencing.