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Innovative Brain Tumor Therapy
1st Edition - October 10, 2014
Authors: Gerardo Caruso, Lucia Merlo, Maria Caffo
Language: English
Hardback ISBN:9781907568596
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eBook ISBN:9781908818744
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Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain…Read more
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Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
All neuroscientists with interest in brain tumor treatment, medical students, researchers, oncologists, neurologists and neurosurgeons.
List of figures
List of abbreviations
About the authors
Introduction
1: Brief introduction on brain tumor epidemiology and state of the art in therapeutics
Abstract
2: Blood–brain barrier pathophysiology in brain tumors
Abstract
3: Brain drug-delivery attempts
Abstract
4: Nanoparticles potential: types, mechanisms of action, actual in vitro and animal studies, recent patents
Abstract
4.1 Nanomedicine and nanoparticles: general overview
4.2 Main types of nanoparticles for drug-delivery systems
4.3 Application in brain tumors
4.4 Recent patents in brain tumors
4.5 Nanotechnology
5: Future scenarios: nanoparticles and stem cells
Abstract
6: Conclusions
Index
No. of pages: 196
Language: English
Edition: 1
Published: October 10, 2014
Imprint: Woodhead Publishing
Hardback ISBN: 9781907568596
eBook ISBN: 9781908818744
GC
Gerardo Caruso
Gerardo Caruso is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy
LM
Lucia Merlo
Lucia Merlo is Neurosurgeon at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy
MC
Maria Caffo
Maria Caffo is Assistant Professor in Neurosurgery, Ph.D in Neurooncology at the Department of Neurosciences, School of Medicine, Neurosurgical Clinic, University of Messina, Italy.
Affiliations and expertise
University of Messina, Italy
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