Inhibitors of the Ras Superfamily G-proteins, Part B

Edited by

  • Fuyuhiko Tamanoi, University of California, Los Angeles, USA
  • Channing J. Der, University of North Carolina at Chapel Hill, Chapel Hill, USA

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.
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Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer


Book information

  • Published: November 2013
  • ISBN: 978-0-12-420146-0

Table of Contents

  1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector Interaction
    Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
  2. An Orthosteric Inhibitor of the RAS-SOS Interaction
    Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
  3. Conformation-Specific Inhibitors of Raf kinases
    Xiaolun Wang and Kristin Schleicher
  4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers
    Leanna Gentry, Ahmed A. Samatar and Channing J. Der
  5. Inhibiting the RAS - PI3K Pathway in Cancer Therapy
    Clare Sheridan and Julian Downward
  6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers
    Jonathan M. Cooper, Brian O. Bodemann and Michael A. White
  7. p21-Activated Kinase Inhibitors
    Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
  8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions
    Fuyuhiko Tamanoi and Jie Lu
  9. Synthetic Lethal Genetic Screens in Ras Mutant Cancers
    Bing Yu and Ji Luo