Inhibitors of the Ras Superfamily G-proteins, Part B book cover

Inhibitors of the Ras Superfamily G-proteins, Part B

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

Audience

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Included in series
The Enzymes

Hardbound, 280 Pages

Published: November 2013

Imprint: Academic Press

ISBN: 978-0-12-420146-0

Contents

    1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector Interaction
      Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
    2. An Orthosteric Inhibitor of the RAS-SOS Interaction
      Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
    3. Conformation-Specific Inhibitors of Raf kinases
      Xiaolun Wang and Kristin Schleicher
    4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers
      Leanna Gentry, Ahmed A. Samatar and Channing J. Der
    5. Inhibiting the RAS - PI3K Pathway in Cancer Therapy
      Clare Sheridan and Julian Downward
    6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers
      Jonathan M. Cooper, Brian O. Bodemann and Michael A. White
    7. p21-Activated Kinase Inhibitors
      Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
    8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions
      Fuyuhiko Tamanoi and Jie Lu
    9. Synthetic Lethal Genetic Screens in Ras Mutant Cancers
      Bing Yu and Ji Luo

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