Inhibitors of the Ras Superfamily G-proteins, Part A book cover

Inhibitors of the Ras Superfamily G-proteins, Part A

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Audience

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Included in series
The Enzymes

Hardbound, 364 Pages

Published: August 2013

Imprint: Academic Press

ISBN: 978-0-12-416749-0

Contents

    1. The Ras superfamily G-proteins
      Fuyuhiko Tamanoi
    2. NMR Study to Identify a Ligand-Binding Pocket in Ras
      Till Maurer and Weiru Wang
    3. The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
      Christian W. Johnson and Carla Mattos
    4. State 1(T) Inhibitors of Activated Ras
      Hans Robert Kalbitzer and Michael Spoerner
    5. Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface 
      Alessandro Di Domizio and Francesco Peri
    6. Development of EHop-016, a Small Molecule Inhibitor of Rac
      Suranganie Dharmawardhane
    7. Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
      Susanne Schmidt and Anne Debant
    8. Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
      Anne Blangy and Philippe Fort
    9. Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
      Dominico Vigil and Channing J. Der
    10. A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
      Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis
    11. Inhibitors of K-Ras Plasma Membrane Localization
      Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock
    12. Ras Chaperons: New Targets for Cancer and Immunotherapy
      Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor

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