Table of ContentsD.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research.M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology.F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment.P. Bach, In Vitro Models for Nephrotoxicity Studies.A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity.M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research.E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies.M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs.E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological andToxicological Assessments.R. Roguet, Cutaneous Pharmacotoxicology In Vitro.H. Spielmann, Ocular Irritation.M.A. Miranda, Phototoxicity of Drugs.I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment.B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing.J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity.A. Guillouzo, Biotransformation of Drugs by Hepatocytes.K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.