In Vitro Methods in Pharmaceutical Research

Edited By

  • Jose Castell, University Hospital 'La Fe', Valencia, Spain
  • Maria Gmez-Lechn, University Hospital 'La Fe', Valencia, Spain


Ideal for pharmacologists and toxicologists in academia and industry. This book will also have great bulk sale potential.


Book information

  • Published: October 1996
  • ISBN: 978-0-12-163390-5


"A compilation of in-depth chapters. This volume makes an important and significant contribution to the field."
--ALAN M. GOLDBERG, PhD, Director, Centre for Alternatives to Animal Testing, Johns Hopkins University

Table of Contents

D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research.M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology.F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment.P. Bach, In Vitro Models for Nephrotoxicity Studies.A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity.M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research.E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies.M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs.E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological andToxicological Assessments.R. Roguet, Cutaneous Pharmacotoxicology In Vitro.H. Spielmann, Ocular Irritation.M.A. Miranda, Phototoxicity of Drugs.I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment.B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing.J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity.A. Guillouzo, Biotransformation of Drugs by Hepatocytes.K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.