Immunology, Inflammation and Diseases of the Eye

Edited by

  • Darlene A. Dartt, Senior Scientist, Schepens Eye Research Institute, Harvard Medical School
  • Reza Dana, Schepens Eye Research Institute, Boston, MA, USA
  • Patricia D'Amore
  • Jerry Niederkorn

This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more.
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Students, researchers and practitioners in ophthalmology and optometry, neuroscience, immunology, physiology, cell biology, pharmacology, and related disciplines


Book information

  • Published: March 2011
  • ISBN: 978-0-12-381974-1

Table of Contents

I. Regulation of the Immune Response of the Eye and Its Dysregulation in Inflammation and Infection
Adaptive Immune System and the Eye: Mucosal Immunity
Adaptive immune system and the eye: T-cell mediated immunity
Innate immune system and the eye
Defense mechanisms of tears and ocular surface
Role of complement in the ocular immune response
Immunoregulatory processes that sustain immune privilege in the eye
Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye
Antigen-presenting cells in the eye and ocular surface
Regenfus and Cursiefen- Angiogenesis in the eye
Dry eye: An immune-based inflammation
Penetrating keratoplasty
Corneal epithelium- response to infection
Immunopathogenesis of HSV Keratitis
Immunopathogenesis of Onchocerciasis (River Blindness)
Immunopathogenesis of pseudomonas keratitis
Immunobiology of acanthomeba karatitis
Pathogenesis of fungal keratitis
Molecular and cellular mechanisms in allergic conjunctivitis
Conjunctiva Immune surveillance
Inflammation of the Conjunctiva
Immunopathogenesis of experimental uveitic diseases
Pathogenesis of Uveitis in humans
Immunobiology of uveal melanoma
Immunobiology of age-related macular degeneration
Pathogenesis and Immunology of Bacterial endophthalmitis

II. Angiogenesis in the Eye and Its Dysfunction in the Retina, Cornea and Vitreous
Orbiatl vascular anatomy
Developmental anatomy of retinal and choroidal vasculature
Development of the retinal vasculature
Physiological Anatomy of the retinal vasculature
Physiological anatomy of the choroidal vasculature
Properties and functions of the vessels of the ciliary body
Anatomy and regulation of the optic nerve blood flow
Angiogenesis in response to hypoxia
Angiogenesis and inflammation
Angiogenesis in wound healing
Hemangiogenesis versus lymphangiogenesis
Innate immunity and angiogenesis
Mechanisms of Angiostasis
Stability and functional integrity of new blood vessels
Vessel regression
Blood-retinal barrier
Breakdown of the blood-retinal barrier
Retinal pigment epithelium barrier
Breakdown of the retinal pigement epithelium blood-retinal barrier
Retinal pigment epithelial-choroid interactions
Macular edema
Central vein occlusion
Pathological retinal angiogenesis
Proliferative vitreoretinopathy
Choroidal neovascularization
The vascular stem cell
Concept of Angiogenic Privilege
Corneal angiogenesis
Avascularity of the cornea
Anti-angiogenic properties of vitreous