Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation
Models in Discovery and Translation
Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.
These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.
AudienceStem cell biologists, cancer biologists, immunologists, hematologists, cardiologists, oncologists, pathologist
- Published: December 2012
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-416004-0
"Self/non-self discrimination is a fundamental requirement of life. Accordingly, vertebrates are equipped with an adaptive immune system that is eminently self-referential: it is selected on self-molecules, sustained by self-molecules, and activated in the presence of self-molecules. Therefore, what might be the consequences of introducing a mature immune system in a novel "non-self" host? The consequences are many. Some are predictable and dreadful (e.g., graft-vs.-host disease), other unexpected and awe-inspiring (e.g., the graft-vs.-leukemia effect). Nonetheless, when allogeneic hematopoietic stem cell transplantation was introduced in medicine, it would have been impossible to anticipate its profound impact on our understanding of immunobiology. GÃ©rard SociÃ© and Bruce Blazar have taken up the gauntlet. They have assembled a dream team of experts who present a clear, comprehensive, critical and exciting picture of the current knowledge in immunobiology of allogeneic hematopoietic stem cell transplantation."--Claude Perreault, PhD, Professor and Canada Research Chair in Immunobiology Institute for Research in Immunology and Cancer UniversitÃ© de MontrÃ©al
Table of Contents
Overview of the immune biology of HSCT; The HLA system; Minor Histocompatibility antigens; In vivo imaging of GVHD and GVL; Immune rejection; The basis of immune deficiency; Tumor associated antigens; Impact of the conditioning regimen; Dendritic cells in GVHD; Costimulatory molecules in GVHD and GVL; Conventional T cells in GvHD and GVL; Regulatory T cells in GVHD and GVL; Th17 in GVHD and GVL; B cells in GVHD and GVL; Cytokines in GVHD and GL; Chemokines in GVHD and GL; Intracellular sensors; Proteomics in GVHD and GVL; The endothelium in GVHD and GVL; Immune Biology of the future