Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Edited by

  • R.C. Kennedy, Department of Microbiology and Immunology, The University of Oklahoma, Health Science Center, Oklahoma City, OK 73190, USA
  • S. Ferrone, Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
  • Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
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Book information

  • Published: November 1997
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-82807-1

Table of Contents

List of Contributors.

General Section
Anti-idiotypes as Vaccines: Theoretical Considerations ( A. Nisonoff)
Anti-idiotypes ( C.A. Bona)
X-ray Crystallographic Studies of the Idiotypic Cascade (N. Ban and A. McPherson)
The Structure and Thermodynamics of Antibody-Protein Antigen Interactions (B.C. Braden and R.J. Poljak)

Autoimmunity Section
Introduction - Idiotypes and Anti-idiotypes (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)
Cross-Reactive Idiotypes in Human Lupus Families (P. Youinou)
Idiotypes of Anti-DNA Antibodies (D. Buskila, M. Abu-Shakra and Y. Shoenfeld)
Idiotypes of Anti-Sm Antibodies (H. Dang and N. Talal)
Idiotypes of anti-Ro and anti-La (Y.B. Dayan, H. Amital and Y. Shoenfeld)
Idiotypes on autoantibodies in myasthenia gravis (A.K. Lefvert)
Idiotypes of ANCA (E. Csernok and W.L. Gross)
Ig Genes and Idiotype of Anti-Mitochondrial Antibodies in Primary Biliary Cirrhosis (P.S.C. Leung and M.E. Gershwin)
Idiotypes of anti-Phospholipid Antibodies (R. Bakimer and Y. Shoenfeld)
Anti-Idiotypic antibodies Against Human Insulin autoantibodies (IAA) (S. Kyurkchiev, M. Stamenova, V. Manolova, V. Tsvetkova, L. Dakovska and I. Kehayov)
Molecular and cellular aspects of human rheumatoid factor production and idiotypes (R.A. Mageed, S.P. Moyes, K.M. Thompson and J.B. Natvig)
Idiotypes of anti-Thyroglobulin Antibodies (Y. Tomer)
Idiotypes of Human Platelet-Specific Antibodies (T.J. Kunicki and D.J. Nugent)
Idiotypes of platelet associated antibodies (Autoimmune thrombocytopenia) (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)
Idiotypes of Natural Autoantobodies and Monoclonal Gammopathies (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)
Idiotypes and anti-idiotypes in Allergy (M.G. Jacquemin and J.-M.R. Saint-Remy)
Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG (Intravenous Immunoglobulin, IVIg) (S.H. Spalter, S. Kaveri and M.D. Kazatchkine)
Manipulation of Autoantibody Idiotypes In Autoimmune Diseases (D. Buskila, M. Abu-Shakra and Y. Shoenfeld)
Anti-Idiotypic Monoclonal Antibody (mAb) to Anti-CD4 mAb as Surrogate of Human CD4 Antigen (Ag) for Active Immunotherapy of Autoimmune Diseases (F. Perosa, M. Scudeletti, F. Indiveri and F. Dammacco)

Infection Section
Introduction (R.C. Kennedy)
Anti-Idiotypic Studies of the Glycoprotine B (gB, UL55) Complex of Human Cytomegalovirus: Mimicry of a Neutralizing Epitope and Development of Diagnostics (E.S. Tackaberry, J. Hamel and B.R. Brodeur)
Anti-Idiotype Antibody in HIV-1-Infected Thrombocytopenic Patients (S. Karpatkin and M.A. Nardi)
An Electron Microscopic View of the Geometry and Dynamics of Idiotype-Anti-Idiotype Interactions (K.H. Roux and N.S. Greenspan)
Probing Human Antibody Diversity in HIV Infection (S. Karray and M. Zouali)
Anti-idiotype mimics of Pseudomonas aeruginosa surface polysaccharides (J.R. Schreiber)
Modulation of the immune response to simian virus 40 large tumor antigen via idiotype-anti-idiotype interactions (M.H. Shearer, H.I. Pass, M. Carbone and R.C. Kennedy)
The perpetual network theory and its putative applications: 21 years later (H.C.J. Ertl)
An Anti-Idiotypic Antibody as a Functional Mirror Image of a Viral Antigen (Y. Thanavala)
Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine (E.-M. Zhou and M. Lin)
An Idiotype Vaccine Against Gram-Negative Bacterial Sepsis (R.E. Ward)
Yeast Killer Toxin-Like Antibodies in Experimental and Clinical Candidasis (L. Polonelli, F. De Bernardis, S. Conti, M. Gerloni and A. Cassone)
Anti-Idiotypic Antibodies and Idiotypic T Cell Selection in HIV Infection:
1. Idiotypes on HIV Specific Antibodies as Disease Markers in AIDS and their Potential as Immunotherapeutic Agents.
2. T Cell Repertoire and Idiotypes in HIV Infection (S. Müller and M. Grant)
Probing Human Polysaccharide-Specific Antibody Repertoires using Anti-Idiotypes (A.H. Lucas)
Anti-Idiotypic Antibodies in HIV-Infected Patients to a Neutralizing Mab and its Complementarity Determining Regions (M. Levi, J. Hinkula and B. Wahren)
Epstein-Barr Virus-Induced Autoimmunity Through Anti-Idiotype Studies (C. Garzelli, M. Incaprera, A. Bazzichi and G. Falcone)

Cancer Section
Introduction (S. Ferrone)
Cancer Therapy with Anti-Idiotypic Antibodies (O. Merimsky, P. Fishman and Y. Shoenfeld)
Immunotherapy of Cancer Patients with Anti-Idiotype Vaccines (M. Bhattacharya-Chatterjee, H. Köhler and K.A. Foon)
Anti-Idiotype Antibodies Mimicking Carcinoembryonic Antigen (M. Monestier)
Immunological and Molecular Characterization of an Idiotypic Cascade Specific for the Human Carcinoembryonic Antigen (M. Neumaier, F.-J. Gaida, D. Pieper, M.A. Sherman and J.E. Shively)
Anti-Idiotypic Antibodies that Mimic the Colorectal Cancer Antigen CO17-1A/GA733: Twelve Years of Pre-Clinical and Clinical Studies (D. Herlyn, R. Somasundaram, L. Jacob, W. Li, J. Zaloudik, H. Maruyama, A. Benden, D. Harris and M. Mastrangelo)
Idiotypic Network Responses and Anti-Idiotypes in Cancer Therapy (J. Fagerberg, P. Ragnhammar and H. Mellstedt)
Anti-Idiotypes in Ovarian Cancer (U. Wagner, H. Schlebusch, J. Schmolling, J. Reinsberg and D. Krebs)
Anti-Idiotype Antibodies in Renal Cell Carcinoma (H. Uemura and E. Oosterwijk)
Clinical Studies with Anti-Idiotypic Monoclonal Antibody BEC2 that Mimics GD3 Ganglioside (P.B. Chapman)
The Anti-Idiotypic Approach to Active Specific Immunotherapy of Malignant Melanoma ( X. Wang, S. Desai, E.J. Noronha, A. Mittelman and S. Ferrone)
Subject Index