Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS book cover

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners.

Audience
Students, drug metabolism scientists and toxicologists in academia and the pharmaceutical industry

Hardbound, 354 Pages

Published: November 2005

Imprint: Elsevier

ISBN: 978-0-444-51710-4

Contents

  • Introduction: LC-MS and Drug Metabolism: A Journey Back in Time, Present Trends and Future Direction (K.B. Alton).
    Strategies for Increasing Throughput for PK Samples in a Drug Discovery Environment (W.A. Korfmacher).
    Commonly Encountered Analytical Problems and their Solutions in Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) Methods Uded in Drug Development (Tapan K. Majumdar).
    Pitfalls in Quantitative LC-MS/MS: Metabolites Contributing to Measured Drug Concentrations (Mohammed Jemal).
    In vitro DMPK Sreening in Drug Discovery, Role of LC-MS/MS (Inhou Chu, Amin A. Nomeir).
    Metabolite Identification by LC-MS: Applications in Drug Discovery and Development (C.E.C.A. Hop, Chandra Prakash).
    Screening for the Assessment of Electrophilic Metabolite Formation Early in Drug Discovery Using HPLC-MS (D.E. Grotz et al.).
    Liquid chromatography Tandem Mass Spectrometry-Based Metabolite Identification Strategies in Pharmaceutical Research (M. Reza Anari et al.).
    Quantification and Structural Elucidation of Low Quantities of Radiolabeled Metabolites Using Microplate Scintillation Counting (MSC) Techniques in Conjunction with LC-MS (Mingshe Zhu et al.).
    Oxidative Metabolites of Drugs and Xenobiotics: LC-MS Methods to Identify and Characterize in Biological Matrices (Ragulan Ramanathan et al.).
    Detection and Charactrization of Highly Polar Metabolites by LC-MS: Proper Selection of LC Column and Use of Stable Isotope Labeled Drug to Study Metabolism of Rabavirin in Rats (S.K. Chowdhury et al.).
    Cytochrome P450 (CYP) and UDP-Glucuronosyltransferase (UGT) Enzymes: Role in Drug Metabolism, Polymorphism, and Identification of their Involvement in Drug Metabolism (A. Ghosal et al.).

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