Hyaluronan in Cancer Biology book cover

Hyaluronan in Cancer Biology

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.

Graduate students, post-doctoral fellows, medical students, and researchers (oncologists, cell biologists, experimental biologists, and biochemists) working in the field of cancer research.

Hardbound, 468 Pages

Published: March 2009

Imprint: Academic Press

ISBN: 978-0-12-374178-3


  • "For decades, hyaluronan researchers have followed with growing interest the slowly developing story of how cancer progression and metastasis are correlated with or regulated by hyaluronan and its catabolic degradation products. Initially trying to understand the role of hyaluronan metabolism in prostate, breast, melanoma and other carcinomas was a bit like the story of the blind men touching and describing an elephant, each with a different impression of what they found. Now, however, our understanding of how hyaluronan is related to cancer biology has come into much clearer focus and this is captured nicely in Hyaluronan in Cancer - a collection of well written research perspectives and summaries from ~20 research groups around the world. The timing of this volume edited by Dr. Stern is excellent - readers can now get an overview and understand the importance of hyaluronan in multiple cancers. The book provides the first state-of-the-field summary and should be a highly useful and cited source for cancer biologists and hyaluronan researchers for many years."

    --Paul H. Weigel, Ph.D., Professor, Chairman George Lynn Cross Research Professor, Ed Miller Endowed Chair Biochemistry & Molecular Biology, The University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, OK, USA

    "Hyaluronan is a major component of the fluid extracellular matrix that surrounds cells and fills the intercellular spaces of tissue. Long known for its fundamental role in tissue development and physiology, hyaluronan’s involvement in cancer progression and metastasis has more recently become the subject of intense multidisciplinary efforts.

    This volume provides a state-of-the-art review of hyaluronan’s role in the cell biology of cancer, its diagnostic and prognostic value, and its potential as a target for therapeutic intervention. Authored by leading researchers in the field, the chapters help bridge the gap between basic science and clinical oncology, providing background and context that will prove valuable to both cancer and hyaluronan researchers for years to come."

    -- Philip A. Band, PhD, NYU Hospital for Joint Diseases, Department of Pharmacology, Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, USA

    "The link between the polysaccharide hyaluronan and cancer is well established. This excellent and comprehensive book brings together expert opinion for a thorough and up-to-date review of the topic. It covers the cell biology of hyaluronan in cancer, the role of hyaluronan receptors and signal transduction pathways and the clinical uses of hyaluronan-related biomaterials as anti-cancer agents. This book is a must read for those interested in the role of hyaluronan and its receptors in cancer biology and therapy."

    --Anthony J. Day, Faculty of Life Sciences, University of Manchester, UK


  • Table of ContentsPreface: Hyaluronan and CancerRobert Stern Section I: Historical Overview1.Association between “acid mucopolysaccharides” and malignancy: an old concept comes of age, finally Robert Stern Section II: Cell Biology of Hyaluronan in Cancer 2.Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cellsMark G. Slomiany and Bryan P. Toole 3.Growth factor regulation of hyaluronan deposition in malignanciesParaskevi Heldin, Eugenia Karousou, and Spyros S. Skandalis4.HYALURONAN BINDING PROTEIN 1 (HABP1) IN CANCER BIOLOGYKasturi Datta Section III: Hyaluronan Receptors and Signal Transduction Pathways 5.CD44 meets merlin and ezrin: Their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of merlinIvan Stamenkovic and Qin Yu 6.Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation and tumor progression Lilly Y.W. Bourguignon7.Adhesion and penetration: two sides of CD44 signal transduction cascades in the context of cancer cell metastasisDavid J.J. Waugh, Ashleigh McClatchey, Nicola Montgomery, and Suzanne McFarlane8.INVOLVEMENT OF CD44, A MOLECULE WITH A THOUSAND FACES, IN CANCER DISSEMINATIONDavid Naor, Shulamit B. Wallach-Dayan, Muayad A. Zahalka, and Ronit Vogt Sionov 9.Rhamm/Hmmr: an intinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation. James B. McCarthy and Eva A. TurleySection IV: Hyaluronan Synthesis10.Altered hyaluronan biosynthesis in cancer progressionNaoki Itano and Koji Kimata Section V: Hyaluronan Degradation, the Hyaluronidases, and the Products of Degradation11.HYALURONDIASE: BOTH A TUMOR PROMOTER AND SUPPRESSORVinata B. Lokeshwar and Marie G. Selzer12.The hyaluronidases in cancer biologyRobert Stern13.Hyaluronan fragments: informational polymers commandeered by cancersKazuki N. Sugahara Section VI : Hyaluronan in Cancer Epithelial-Stromal Interactions14.Hyaluronan in human tumors: importance of stromal and cancer cell-associated hyaluronanRaija H. Tammi , Anne H. Kultti, Veli-Matti Kosma, Risto Pirinen, Päivi Auvinen, and Markku I. Tammi15.THE ONCOFETAL PARADIGM REVISITED: MSF AND HA AS CONTEXTUAL DRIVERS OF CANCER PROGRESSIONSeth L. Schor, Ana M. Schor, Ian R. Ellis, Sarah J. Jones, Margaret Florence, Jacqueline Cox, and Anne-Marie Woolston Section VII: Hyaluronan and Individual Cancers16.Hyaluronan synthesis and turnover in prostate cancer Melanie A. Simpson 17.Role of hyaluronan in melanoma progressionCarl Gebhardt, Marco Averbeck, Ulf Anderegg, and Jan C. Simon 18.Role of Hyaluronan metabolism in the initiation, invasion and metastasis of Breast cancerTracey J. Brown and Natalie Thomas Section VIII: Clinical Uses of Hyaluronan-Related Biomaterials as Anti-Cancer Agents 19. Clinical application of hyaluronidase in combination cancer chemotherapy: a historic perspectiveGerhard Baumgartner and Gerhard Hamilton20.Exploring the hyaluronan-CD44 interaction for cancer therapyVirginia M. Platt and Francis C. Szoka Section IX: A New Perspective 21.Hyaluronidase-2 and its role as a cell-entry receptor for sheepretroviruses that cause contagious respiratory tract cancersA. Dusty Miller


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