In this important reference work, Zeliger catalogs the known effects of chemical mixtures
on the human body and also proposes a framework for understanding and predicting their
actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The
authorâs focus is on illnesses that ensue following exposures to mixtures of chemicals
that cannot be attributed to any one component of the mixture.
In the first part the mechanisms of chemical absorption at a molecular and
macromolecular level are explained, as well as the bodyâs methods of defending itself
against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,
looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which
includes numerous case studies, examines specific effects of particular mixtures on
particular body systems and organs and presents a theoretical framework for predicting
what the effects of uncharacterized mixtures might be. Part IV covers regulatory
requirements and the need to adjust recommended exposure levels for products
containing mixtures. It also contains recommendations on how to limit exposure to
mixtures in the products we use and on how to limit release of mixtures into the
Providing brief summaries of each mixture and its effects, Zeliger provides a
comprehensive reference, a jumping off point for professionals (with extensive chapter
bibliographies) and an introduction to the topic for those studying traditional toxicology.
Addressing many inadequately understood illnesses and conditions such as asthma,
infertility and cancer, it will also be of interest to health professionals, environmental
scientists and lawyers.