Human Toxicology of Chemical Mixtures book cover

Human Toxicology of Chemical Mixtures

In this important reference work, Zeliger catalogs the known effects of chemical mixtures

on the human body and also proposes a framework for understanding and predicting their

actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The

author’s focus is on illnesses that ensue following exposures to mixtures of chemicals

that cannot be attributed to any one component of the mixture.

In the first part the mechanisms of chemical absorption at a molecular and

macromolecular level are explained, as well as the body’s methods of defending itself

against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,

looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which

includes numerous case studies, examines specific effects of particular mixtures on

particular body systems and organs and presents a theoretical framework for predicting

what the effects of uncharacterized mixtures might be. Part IV covers regulatory

requirements and the need to adjust recommended exposure levels for products

containing mixtures. It also contains recommendations on how to limit exposure to

mixtures in the products we use and on how to limit release of mixtures into the


Providing brief summaries of each mixture and its effects, Zeliger provides a

comprehensive reference, a jumping off point for professionals (with extensive chapter

bibliographies) and an introduction to the topic for those studying traditional toxicology.

Addressing many inadequately understood illnesses and conditions such as asthma,

infertility and cancer, it will also be of interest to health professionals, environmental

scientists and lawyers.


Primary audience:

• Industrial Health and Safety personnel

• Chemists and Chemical Engineers working in sectors such as the chemical

industry, personal care and cosmetics, pharmaceuticals, etc.

• Environmental Scientists and Engineers

• Toxic Waste Managers

• Toxicologists

• Health Professionals

Secondary audience (professional): Food manufacturers, laboratory workers,

environmental and OSHA training personnel, industrial risk assessors, forensic

investigators and attorneys involved in toxic torts litigation, disease prevention advocacy

groups, students and researchers.

Hardbound, 574 Pages

Published: June 2011

Imprint: William Andrew

ISBN: 978-1-4377-3463-8


  • PART I

    1) Introduction to Chemical Toxicology of Mixtures

    2) Health Effects of Exposures to Chemical Mixtures

    3) Absorption of Chemical Mixtures

    4) Chemical Toxicology

    PART II Exposures to Chemical Mixtures

    5) Scope and sources of toxic exposures

    6) In Utero Exposure

    7) Air Pollution

    8) Water Pollution

    9) Soil Pollution

    10) Food

    11) Chemicals In and Around The Home

    12) Sick Building Syndrome

    13) Industrial Exposure

    14) Pesticides

    15) Alcohol and Tobacco: Recreational Toxins

    16) Electromagnetic Radiation and Toxic Exposure

    PART III Mixture Effects on Body Systems

    17) Respiratory System

    18) Nervous System

    19) Developmental Neurotoxicology

    20) Autism: Effect of Maternal Exposure to Neurotoxic Chemcials

    21) Attention Deficit Hyperactivity Disorder (ADHD)

    22) Endocrine System

    23) Toxic Infertility

    24) Teratogens

    25) Immune System

    26) Chemical Sensitivity: Multiple Chemical Sensitivity (MCS)

    27) Skin

    28) Musculoskeletal System

    29) Cardiovascular System

    30) Liver

    31) Kidneys

    32) Cancer

    33) Childhood Cancer

    34) Cancer Clusters

    PART IV Regulatory Requirements

    35) Regulatory Requirements

    36) Conclusions and Recommendations


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