Human Toxicology of Chemical Mixtures

Toxic Consequences Beyond the Impact of One-Component Product and Environmental Exposures


  • Harold Zeliger

This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals.
View full description


Toxicologists, medical practitioners, industrial hygienists, safety personnel, chemical formulators in the chemical, personal care, cosmetic, pharmaceutical, industrial, and consumer chemical product industries. Other segments include food manufacturers, laboratory workers, environmental and OSHA training personnel, forensic investigators and attorneys involved in toxic torts litigation.


Book information

  • Published: June 2008
  • ISBN: 978-0-8155-1589-0


"An easy-to-read book that should be in any toxicologist's library. With an enormous effort of synthesis, the author has treated a wide variety of subjects in the emerging field of chemical mixtures." -- Arturo Ortego, M.D., School of Medicine and Health Sciences, Rovira I Virgili University, Reus, Spain

Table of Contents

PART I Introduction to Chemical Toxicology of MixturesIntroductionHealth Effects of Exposures to Chemical MixturesAbsorption of Chemical MixturesChemical ToxicologyPART II Exposures to Chemical MixturesScope and sources of toxic exposuresIn Utero ExposureAir PollutionWater PollutionSoil PollutionFoodChemicals In and Around The HomeSick Building SyndromeIndustrial ExposurePesticidesAlcohol and Tobacco: Recreational ToxinsElectromagnetic Radiation and Toxic ExposurePART III Mixture Effects on Body SystemsRespiratory SystemNervous SystemDevelopmental NeurotoxicologyAutism: Effect of Maternal Exposure to Neurotoxic ChemcialsAttention Deficit Hyperactivity Disorder (ADHD)Endocrine SystemToxic InfertilityTeratogensImmune SystemChemical Sensitivity: Multiple Chemical Sensitivity (MCS)SkinMusculoskeletal SystemCardiovascular SystemLiverKidneysCancerChildhood CancerCancer ClustersPART IV REGULATORY REQUIREMENTS, CONCLUSIONSRegulatory RequirementsConclusions