Human Genes and Genomes

Science, Health, Society


  • Leon Rosenberg, Department of Molecular Biology and the Woodrow Wilson School of Public and International Affairs Princeton University Princeton, NJ, USA
  • Diane Rosenberg, Scientific Publishing Consultant, Lawrenceville, NJ

In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences.  The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships.   In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life.  With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and  its relevance across disciplines.
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Book information

  • Published: May 2012
  • ISBN: 978-0-12-385212-0


". . . a beautifully written and insightful genetics book that hits all the right notes. Major principles are illustrated in the context of real disease, both Mendelian and complex, which keeps the relevance high."

Michael J. Dougherty, PhD, Director of Education, American Society of Human Genetics

"This thoughtful and scholarly book, teaching about common traits and rare inherited disorders, is beautifully written and accessible to science students and non-science students alike."

Margretta Seashore, MD, Director, Genetic Consultation Service and Director, Biochemical Disease Detection Laboratory, Department of Laboratory Medicine, Yale University School of Medicine

"A master story teller and one of the founders of the field, Rosenberg tells the story of human genetics as few others can - anchored in history but with a fresh eye towards what the study of the human genome teaches us about genes and their importance for both biology and medicine."

Huntington F. Willard, PhD, Director, Duke Institute for Genome Sciences & Policy, Duke University

Table of Contents

Part 1: Introduction and Core Concepts
Chapter 1 - Framing the Field
Chapter 2 - Introducing the CORE CONCEPTS
Chapter 3 - Genetics
Chapter 4 - Growth, Development, and Reproduction
Chapter 5 - Transmission of Genes
Chapter 6 - Structure of Genes, Chromosomes, and Genomes
Chapter 7 - Expression of Genes and Genomes
Chapter 8 - Mutation
Chapter 9 - Biological Evolution
Chapter 10 - Human Individuality

Part 2: Genetic Disorders
Chapter 11 - Chromosome Abnormalities
Chapter 12 - Single Gene Defects
Chapter 13 - Multifactorial Traits
Chapter 14 - Disorders of Variable Genomic Architecture
Chapter 15 - Birth Defects
Chapter 16 - The Genetics of Cancer
Chapter 17 - Detection and Treatment of Genetic Disorders

Part 3: Populations and Individuals
Chapter 18 - Population and Evolutionary Genetics
Chapter 19 - Personalized Genetics and Genomics

Additional Reading
Appendix 1 - Answers to Review Questions
Appendix 2 - Credits and Permissions