Human Chorionic Gonadotropin (hCG) book cover

Human Chorionic Gonadotropin (hCG)

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.

Audience

Researchers in reproductive medicine, oncology, and endocrinology

Hardbound, 446 Pages

Published: December 2014

Imprint: Elsevier

ISBN: 978-0-12-800749-5

Contents

  • Part A. Introduction
    1. The Expanding World of hCG
    2. History and Introduction to Human Chorionic Gonadotropin (hCG), A Group of Five Independent Super-Growth Factors.

    Part B. Synthesis, Structure and Action Site
    3. The Molecular Genetics of hCG
    4. Structure, Synthesis and Secretion of hCG
    5. Three Dimensional Structures of hCG and Hyperglycosylated hCG
    6. Structures of hCG Free α- and β-Subunits
    7. Glycobiology of hCG
    8. Detecting hCG and hCG Cariants Using MALDI-ToF Mass Spectrometry
    9. The hCG/LH Hormone Receptor
    10. TGFβ-II Autocrine Receptor

    Part C. Continuous Dissociation and Degradation
    11. Degradation Products of hCG, Hyperglycosylated hCG, and
    Free β-Subunit

    Part D. Biological Function: Pregnancy

    12. Pregnacy-1, Functions Pre-Implantation and at Blastocyst Implantation
    13. Pregnancy-2, Maintenance of Gestation
    14. Pregnancy-3, Creation and Continuation of Hemochorial Placentation
    15. Paradigm Shift on the Targets of hCG Actions

    Part E. Biological Function: Normal Pituitary
    16. Pituitary Sulfated hCG

    Part F. Biological Function: Evolution
    17. Evolution

    Part G. Biological Function: Gestational Trophoblastic
    Disease
    18. Biological Functions of Hyperglycosylated hCG
    19. Gestational Trophoblastic Diseases

    Part H. Biological Function: Cancer
    20. Cancer-1, hCG Variants as a Tumor Marker
    21. Cancer-2, hCG Variants Drive Malignancies
    22. Cancer-3, Tying Everything Together
    23. Biological Function of the Free β-Subunit: Expression and Treatment Target in Cancer
    24. hCG and Breast Cancer Conundrum

    Part I. Clinical Applications
    25. Use of hCG in Reproductive Dysfunction
    26. hCG in Assisted Reproduction
    27. Illicit Use of hCG in Dietary Programs and Use to Promote Anabolism
    28. Positive hCG Tests: Causes Other than Pregnancy

    Part J. Assays and Antibodies
    29. Antibodies and hCG tests
    30. Problems with Today’s hCG Pregnancy Tests
    31. The Future and a New Generation of Pregnancy Tests

    Part K. Test Applications and Standards
    32. Detecting Down Syndrome Pregnancies and Preeclampsia
    33. The Biology of Gestational Trophoblastic Disease
    34. Hyperglycosylated hCG and Free ß-subunit Markers of Gestational Trophoblastic Diseases
    35. Quiescent Gestational Trophoblastic Disease and Minimally-Aggressive Disease
    36. Background hCG
    37. hCG Standards

    Part L. Methods
    38. hCG and Hyperglycosylated hCG Purification and Analysis from
    Serum, Urine, and Culture Fluids

    Part M. Ethics, Comments and the Future
    39. Ethic, Texas and Politics
    40. Summary: hCG a Remarkable Molecule
    41. hCG and the Future

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