Human Chorionic Gonadotropin (hGC) book cover

Human Chorionic Gonadotropin (hGC)

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

Audience
Researchers and clinicians in obstetrics, gynecology, clinical chemistry, endocrinology, reproductive medicine and oncology

Hardbound, 400 Pages

Published: September 2010

Imprint: Elsevier

ISBN: 978-0-12-384907-6

Contents

  • INTRODUCTION

     Chapter 1: THE EXPANDING WORLD OF hCG

    Robert Hussa

    Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES
    Laurence Cole

    Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION
    Laurence Cole

     GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG

    Chapter 4: THE MOLECULAR GENETICS OF hCG
    Stephen Butler

    Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG
    Laurence Cole, PhD and Stephen Butler

    Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG
    Laurence Cole

    Chapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT
    Laurence Cole

    Chapter 8: GLYCOBIOLOGY OF hCG
    Akira Kobata

    Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT
    Laurence Cole

    Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCG
    Laurence Cole

     

    BIOLOGICAL FUNCTION OF hCG

    Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS

    CV Rao

    Chapter 12: THE hCG RECEPTOR

    Laurence Cole and Stephen Butler

    Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCG
    Laurence Cole

    Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER

    Steven Butler and Ray Iles

     

    CLINICAL APPLICATIONS

    Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTION
    Cisco Byrn

    Chapter 16: hCG IN THE IVF CLINIC
    Ervin Jones, Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM
    Laurence Cole  

    hCG TESTS

    Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTS
    Laurence Cole

    Chapter 19: QUANTITATIVE hCG ASSAYS
    Laurence Cole

    Chapter 20: FALSE-POSITIVE hCG ASSAYS
    Laurence Cole

    Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYS
    Laurence Cole

    Chapter 22: POINT-OF-CARE PREGNANCY TESTS
    Laurence Cole Chapter 23: OVER-THE-COUNTER PREGANCY TESTS
    Laurence Cole Chapter 24: hCG STANDARDS
    Ulf Stenman

     

    TEST APPLICATIONS

    Chapter 25: BACKGROUND hCG
    Laurence Cole Chapter 26: PREGNANCY TESTING
    Laurence Cole

    Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES
    Laurence Cole

    Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA
    Laurence Cole

    Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES

    Laurence Cole

    Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS

    Laurence Cole and Carolyn Muller

    Chapter 31: PITUITARY hCG AND FAMILIAL hCG
    Laurence Cole Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES
    Laurence Cole

     

    BASIC METHODS

    Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS

    Laurence Cole

    Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG

    Laurence Cole

    Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES

    Laurence Cole   

    EVOLUTION, SUMMARY AND THE FUTURE

    Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCER
    Laurence Cole

    Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULE
    Laurence Cole

    Chapter 38: hCG AND THE FUTURE
    Laurence Cole

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