Histopathology of Preclinical Toxicity Studies

Interpretation and Relevance in Drug Safety Evaluation


  • Peter Greaves

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology.
View full description


Clinical Pharmacologists; Toxicologists; Histopathologists; Drug Regulatory Agents; Drug Safety authorities; Pharmaceutical Industries; Academic; Research


Book information

  • Published: February 2007
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-52771-4

Table of Contents

IntroductionIntegumentary SystemMammary GlandHaemopoietic and Lymphatic SystemsMusculoskeletal SystemRespiratory TractCardiovascular SystemGastrointestinal tract