Histopathology of Preclinical Toxicity Studies
Interpretation and Relevance in Drug Safety Evaluation
- P. Greaves, University of Leicester, UK
This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably prior to their first administration to humans and during early clinical trials.
Covering virtually all aspects of drug-induced pathology in preclinical toxicity studies, the book is termed the 'gold standard' in the illustration of histopathology. This second revised edition continues to fill the gap for pathology literature relating to the development of new medicines and assessment of their safety based on preclinical studies. In addition to the updated references this edition contains many older references, some out of reach of modern computer based search tools.
Pharmaceutical Industries (Toxicology and Drug safety departments), Drug Regulatory Authorities; Clinical Pharmacologists; Medical Libraries
- Published: December 2000
- Imprint: ELSEVIER
- ISBN: 978-0-444-50514-9
...The present second edition of this comprehensive and ambitious compendium is an updated version of the first issue published in 1990. ...I recommend the book for those who are directly involved in standard preclinical studies on effects of drugs and related chemicals.
T. Lang, Archive of Fishery and Marine Research
...This work is a veritable 'tour-de-force' of which the author can be justifiably proud. It is the second edition of the book, first published about twelve years ago, and this version, like the previous, is exemplary. If this is your field then this is your book. Excellent.
S. Mitchell, ISSX Newsletter