Hematology
Basic Principles and Practice, Expert Consult Premium Edition - Enhanced Online Features and Print
By- Ronald Hoffman, MD, Professor of Hematology and Medical Oncology, the Mount Sinai School of Medicine, New York, New York
- Edward Benz, MD, President, Dana-Farber Cancer Institute; Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, Professor of Pathology, Harvard Medical School, Boston, Massachusetts
- Leslie Silberstein, MD, Professor of Pathology, HMS; Director, Joint Program in Transfusion Medicine; Children's Hospital Boston; Brigham and Women's Hospital; Dana-Farber Cancer Institute; Senior Investigator, IDI; Director, Center for Human Cell Therapy, IDI; Boston, Massachusetts
- Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas
- Jeffrey Weitz, MD, Professor of Medicine,McMaster University School of Medicine; Executive Director of the Thrombosis and Atherosclerosis Research Institute; Canada Research Chair in Thrombosis; Hamilton, Ontario, Canada
- John Anastasi, MD, Associate Professor; Assistant Director, Hematopathology; Medical Director, Flow Cytometry; Department of Pathology, The University of Chicago; Chicago, Illinois
Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options.
Hardbound, 2384 Pages
Published: November 2012
Imprint: Churchill Livingstone
ISBN: 978-1-4377-2928-3
Contents
PART I: Molecular and Cellular Basis of Hematology
1 Anatomy and Pathophysiology of the Gene
2 Genomic Approaches to Hematology
3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism4 Protein Synthesis, Processing, and Trafficking
5 Protein Architecture: Relationship of Form and Function6 Signaling Transduction and Regulation of Cell Metabolism
7 Pharmacogenomics and Hematologic DiseasesPART II: Cellular Basis of Hematology8 Hematopoietic Stem Cell Biology
9 Hematopoietic Microenvironment
10 Cell Adhesion11 Hematopoietic Cell Trafficking and Chemokines
12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization13 Vascular Growth in Health and Disease
14 Principles of Cytokine Signaling15 Control of Cell Division
16 Cell DeathPART III: Immunologic Basis of Hematology17 Overview and Compartmentalization of the Immune System
18 B-Cell Development
19 T-Cell Immunity20 Natural Killer Cell Immunity
21 Dendritic Cell Biology22 Complement and Immunoglobulin Biology
23 Tolerance and AutoimmunityPART IV: Disorders of Hematopoietic Cell Development24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
25 Granulocytopiesis and Monocytopoiesis
26 Thrombocytopoiesis27 Inherited Forms of Bone Marrow Failure
28 Aplastic Anemia29 Paroxysmal Nocturnal Hemoglobinuria
30 Acquired Disorders of Red Cell, White Cell, and Platelet ProductionPART V: Red Blood Cells31 Pathobiology of the Human Erythrocyte and Its Hemoglobins
32 Approach to Anemia in the Adult and Child
33 Pathophysiology of Iron Homeostasis34 Disorders of Iron Homeostasis: Iron Deficiency and Overload
35 Anemia of Chronic Diseases36 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
37 Megaloblastic Anemias38 Thalassemia Syndromes
39 Pathobiology of Sickle Cell Disease40 Sickle Cell Disease - Clinical Features and Management
41 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias42 Red Blood Cell Enzymopathies
43 Red Blood Cell Membrane Disorders44 Autoimmune Hemolytic Anemia
45 Extrinsic Nonimmune Hemolytic AnemiasPART VI: Non-Malignant Leukocytes46 Neutrophilic Leukocytosis, Neutropenia, Monocytosis and Monocytopenia
47 Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia and Hypogammaglobulinemia
48 Disorders of Phagocyte Function49 Congenital Disorders of Lymphocyte Function
50 Histiocytic Disorders51 Lysosomal Storage Diseases: Perspectives and Principles
52 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated DiseasesPART VII: Hematologic Malignancies53 Progress in the Classification of Myeloid Neoplasms: Clinical Implications
54 Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies
55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies56 Radiation Therapy in the Treatment of Hematologic Malignancies
57 Pathobiology of Acute Myeloid Leukemia58 Clinical Manifestations and Treatment of Acute Myeloid Leukemia
59 Myelodysplastic Syndromes: Biology and Treatment60 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
61 Acute Myeloid Leukemia in Children62 Myelodysplastic and Myeloproliferative Neoplasms in Children
63 Pathobiology of Acute Lymphoblastic Leukemia64 Clinical Manifestations and Treatment of Acute Lymphoblastic Leukemia in Children
65 Acute Lymphoblastic Leukemia in Adults66 Chronic Myeloid Leukemia
67 The Polycythemias68 Essential Thrombocythemia
69 Primary Myelofibrosis70 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
71 Mast Cells and Systemic Mastocytosis72 The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
73 Origins of Hodgkin Lymphoma74 Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy
75 Origin of Non-Hodgkin Lymphoma76 Chronic Lymphocytic Leukemia
77 Hairy Cell Leukemia78 Clinical Manifestations and Treatment of Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
79 Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma80 Mantle Cell Lymphoma
81 Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma82 Virus-Associated Lymphoma
83 Malignant Lymphomas in Childhood84 T-Cell Lymphomas
85 Plasma Cell Neoplasms86 Waldenstrom Macroglobulinemia and Lymphoplasmacytic Lymphoma
87 Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)PART VIII: Comprehensive Care of Patients with Hematologic Malignancies88 Clinical Approach to Infections in the Compromised Host
89 Indwelling Access Devices
90 Nutritional Issues in Patients with Hematologic Malignancies91 Psychosocial Aspects of Hematologic Disorders
92 Pain Management and Antiemetic Therapy in Hematologic Disorders93 Palliative Care
94 Late Complications of Hematologic Diseases and Their TherapiesPART IX: Cell-Based Therapies95 Overview and Historical Perspective of Cell-Based Therapies
96 Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization
97 Preclinical Process of Cell-Based Therapies98 Graft Engineering and Cell Processing
99 Principles of Cell-Based Genetic Therapies100 Mesenchymal Stromal Cells
101 T Cell Therapy of Hematological Diseases102 Natural Killer Cell-Based Therapies
103 Dendritic Cell TherapiesPART X: Transplantation104 Overview of Hematopoietic Cell Transplantation
105 Indications and Outcome of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
106 Unrelated Donor Hematopoietic Cell Transplantation107 Haploidentical Hematopoietic Cell Transplantation
108 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies109 Graft-versus-Host Disease and Graft-versus-Leukemia Responses
110 Complications After Hematopoietic Stem Cell TransplantationPART XI: Transfusion Medicine111 Human Blood Group Antigens and Antibodies
112 Principles of Red Blood Cell Transfusion
113 Principles of Platelet Transfusion Therapy114 Human Leukocyte Antigen and Human Neutrophil Antigen Systems
115 Principles of Neutrophil (Granulocyte) Transfusions116 Principles of Plasma Transfusion: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
117 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins118 Transfusion Therapy for Coagulation Factor Deficiencies
119 Hemapheresis120 Transfusion Reactions to Blood and Cell Therapy Products
121 Transfusion-Transmitted Diseases122 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation
123 Pediatric Transfusion MedicinePART XII: Hemostasis and Thrombosis124 Overview of Hemostasis and Thrombosis
125 The Blood Vessel Wall
126 Megakaryocyte and Platelet Structure127 Molecular Basis for Platelet Function
128 Molecular Basis of Blood Coagulation129 Regulatory Mechansims in Hemostasis
130 Clinical Approach to the Patient with Bleeding or Bruising131 Laboratory Evaluation of Hemostatic and Thrombotic Disorders
132 Acquired Disorders of Platelet Function133 Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
134 Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution135 Heparin-Induced Thrombocytopenia
136 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome137 Hemophilia A and B
138 Inhibitors in Hemophilia A and B139 Rare Coagulation Factor Deficiencies
140 Structure, Biology, and Genetics of von Willebrand Factor141 Disseminated Intravascular Coagulation
142 Hypercoagulable States143 Antiphospholipid Syndrome
144 Venous Thromboembolism145 Mechanical Interventions in Arterial and Venous Thrombosis
146 Atherothrombosis147 Stroke
148 Acute Coronary Syndromes149 Atrial Fibrillation
150 Peripheral Artery Disease151 Antithrombotic Drugs
152 Disorders of Coagulation in the NeonatePART XIII: Consultative Hematology153 Hematologic Changes in Pregnancy
154 Hematologic Manifestations of Childhood Illness
155 Hematologic Manifestations of Liver Disease156 Hematologic Manifestations of Systemic Disease: Renal Disease
157 Hematologic Manifestations of Cancer158 Integrative Therapies in Patients with Hematologic Diseases
159 Hematologic Manifestations of HIV/AIDS160 Hematologic Aspects of Parasitic Diseases
161 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis162 The Spleen and Its Disorders
163 Hematology in Aging164 (Online Only) Resources For The Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations
