Hematology book cover


Basic Principles and Practice, Expert Consult Premium Edition - Enhanced Online Features and Print

Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options.

Hardbound, 2384 Pages

Published: November 2012

Imprint: Churchill Livingstone

ISBN: 978-1-4377-2928-3


  • "This outstanding book will be a great resource to hematologists in practice and in training all over the world. It is current and, with plans for continually supplementing the online version as more information becomes available, it will continue to be up to date."

    -Kehinde Adekola, MBBS Northwestern University Feinberg School of Medicine

    5 Star - Doody's Rating, March 2013

    "There has been a significant improvement in general layout and visual appearence between the 5th and 6th editions. The book is now in full colour throughout, with numerous sections of added and useful information contained in blue and red coloured boxes...The entire text of the book, including downloadable images, is available online, and includes updates to the book - such as the recent addition of arsenic trioxide and ATRA as treatment for acute promyelocytic leukaemia...for the truly discerning haematologist, only th fullest detail will suffice, and only Hoffman's Hematology: Basic Principles and Practice will do."

    Haemtrainee, Sept 2013



  • PART I: Molecular and Cellular Basis of Hematology

    1 Anatomy and Pathophysiology of the Gene

    2 Genomic Approaches to Hematology

    3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism

    4 Protein Synthesis, Processing, and Trafficking

    5 Protein Architecture: Relationship of Form and Function

    6 Signaling Transduction and Regulation of Cell Metabolism

    7 Pharmacogenomics and Hematologic Diseases

    PART II: Cellular Basis of Hematology

    8 Hematopoietic Stem Cell Biology

    9 Hematopoietic Microenvironment

    10 Cell Adhesion

    11 Hematopoietic Cell Trafficking and Chemokines

    12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

    13 Vascular Growth in Health and Disease

    14 Principles of Cytokine Signaling

    15 Control of Cell Division

    16 Cell Death

    PART III: Immunologic Basis of Hematology

    17 Overview and Compartmentalization of the Immune System

    18 B-Cell Development

    19 T-Cell Immunity

    20 Natural Killer Cell Immunity

    21 Dendritic Cell Biology

    22 Complement and Immunoglobulin Biology

    23 Tolerance and Autoimmunity

    PART IV: Disorders of Hematopoietic Cell Development

    24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

    25 Granulocytopiesis and Monocytopoiesis

    26 Thrombocytopoiesis

    27 Inherited Forms of Bone Marrow Failure

    28 Aplastic Anemia

    29 Paroxysmal Nocturnal Hemoglobinuria

    30 Acquired Disorders of Red Cell, White Cell, and Platelet Production

    PART V: Red Blood Cells

    31 Pathobiology of the Human Erythrocyte and Its Hemoglobins

    32 Approach to Anemia in the Adult and Child

    33 Pathophysiology of Iron Homeostasis

    34 Disorders of Iron Homeostasis: Iron Deficiency and Overload

    35 Anemia of Chronic Diseases

    36 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias

    37 Megaloblastic Anemias

    38 Thalassemia Syndromes

    39 Pathobiology of Sickle Cell Disease

    40 Sickle Cell Disease - Clinical Features and Management

    41 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias

    42 Red Blood Cell Enzymopathies

    43 Red Blood Cell Membrane Disorders

    44 Autoimmune Hemolytic Anemia

    45 Extrinsic Nonimmune Hemolytic Anemias

    PART VI: Non-Malignant Leukocytes

    46 Neutrophilic Leukocytosis, Neutropenia, Monocytosis and Monocytopenia

    47 Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia and Hypogammaglobulinemia

    48 Disorders of Phagocyte Function

    49 Congenital Disorders of Lymphocyte Function

    50 Histiocytic Disorders

    51 Lysosomal Storage Diseases: Perspectives and Principles

    52 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases

    PART VII: Hematologic Malignancies

    53 Progress in the Classification of Myeloid Neoplasms: Clinical Implications

    54 Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies

    55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies

    56 Radiation Therapy in the Treatment of Hematologic Malignancies

    57 Pathobiology of Acute Myeloid Leukemia

    58 Clinical Manifestations and Treatment of Acute Myeloid Leukemia

    59 Myelodysplastic Syndromes: Biology and Treatment

    60 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults

    61 Acute Myeloid Leukemia in Children

    62 Myelodysplastic and Myeloproliferative Neoplasms in Children

    63 Pathobiology of Acute Lymphoblastic Leukemia

    64 Clinical Manifestations and Treatment of Acute Lymphoblastic Leukemia in Children

    65 Acute Lymphoblastic Leukemia in Adults

    66 Chronic Myeloid Leukemia

    67 The Polycythemias

    68 Essential Thrombocythemia

    69 Primary Myelofibrosis

    70 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes

    71 Mast Cells and Systemic Mastocytosis

    72 The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas

    73 Origins of Hodgkin Lymphoma

    74 Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy

    75 Origin of Non-Hodgkin Lymphoma

    76 Chronic Lymphocytic Leukemia

    77 Hairy Cell Leukemia

    78 Clinical Manifestations and Treatment of Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)

    79 Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma

    80 Mantle Cell Lymphoma

    81 Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma

    82 Virus-Associated Lymphoma

    83 Malignant Lymphomas in Childhood

    84 T-Cell Lymphomas

    85 Plasma Cell Neoplasms

    86 Waldenstrom Macroglobulinemia and Lymphoplasmacytic Lymphoma

    87 Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)

    PART VIII: Comprehensive Care of Patients with Hematologic Malignancies

    88 Clinical Approach to Infections in the Compromised Host

    89 Indwelling Access Devices

    90 Nutritional Issues in Patients with Hematologic Malignancies

    91 Psychosocial Aspects of Hematologic Disorders

    92 Pain Management and Antiemetic Therapy in Hematologic Disorders

    93 Palliative Care

    94 Late Complications of Hematologic Diseases and Their Therapies

    PART IX: Cell-Based Therapies

    95 Overview and Historical Perspective of Cell-Based Therapies

    96 Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization

    97 Preclinical Process of Cell-Based Therapies

    98 Graft Engineering and Cell Processing

    99 Principles of Cell-Based Genetic Therapies

    100 Mesenchymal Stromal Cells

    101 T Cell Therapy of Hematological Diseases

    102 Natural Killer Cell-Based Therapies

    103 Dendritic Cell Therapies

    PART X: Transplantation

    104 Overview of Hematopoietic Cell Transplantation

    105 Indications and Outcome of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults

    106 Unrelated Donor Hematopoietic Cell Transplantation

    107 Haploidentical Hematopoietic Cell Transplantation

    108 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies

    109 Graft-versus-Host Disease and Graft-versus-Leukemia Responses

    110 Complications After Hematopoietic Stem Cell Transplantation

    PART XI: Transfusion Medicine

    111 Human Blood Group Antigens and Antibodies

    112 Principles of Red Blood Cell Transfusion

    113 Principles of Platelet Transfusion Therapy

    114 Human Leukocyte Antigen and Human Neutrophil Antigen Systems

    115 Principles of Neutrophil (Granulocyte) Transfusions

    116 Principles of Plasma Transfusion: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins

    117 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins

    118 Transfusion Therapy for Coagulation Factor Deficiencies

    119 Hemapheresis

    120 Transfusion Reactions to Blood and Cell Therapy Products

    121 Transfusion-Transmitted Diseases

    122 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation

    123 Pediatric Transfusion Medicine

    PART XII: Hemostasis and Thrombosis

    124 Overview of Hemostasis and Thrombosis

    125 The Blood Vessel Wall

    126 Megakaryocyte and Platelet Structure

    127 Molecular Basis for Platelet Function

    128 Molecular Basis of Blood Coagulation

    129 Regulatory Mechansims in Hemostasis

    130 Clinical Approach to the Patient with Bleeding or Bruising

    131 Laboratory Evaluation of Hemostatic and Thrombotic Disorders

    132 Acquired Disorders of Platelet Function

    133 Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura

    134 Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution

    135 Heparin-Induced Thrombocytopenia

    136 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

    137 Hemophilia A and B

    138 Inhibitors in Hemophilia A and B

    139 Rare Coagulation Factor Deficiencies

    140 Structure, Biology, and Genetics of von Willebrand Factor

    141 Disseminated Intravascular Coagulation

    142 Hypercoagulable States

    143 Antiphospholipid Syndrome

    144 Venous Thromboembolism

    145 Mechanical Interventions in Arterial and Venous Thrombosis

    146 Atherothrombosis

    147 Stroke

    148 Acute Coronary Syndromes

    149 Atrial Fibrillation

    150 Peripheral Artery Disease

    151 Antithrombotic Drugs

    152 Disorders of Coagulation in the Neonate

    PART XIII: Consultative Hematology

    153 Hematologic Changes in Pregnancy

    154 Hematologic Manifestations of Childhood Illness

    155 Hematologic Manifestations of Liver Disease

    156 Hematologic Manifestations of Systemic Disease: Renal Disease

    157 Hematologic Manifestations of Cancer

    158 Integrative Therapies in Patients with Hematologic Diseases

    159 Hematologic Manifestations of HIV/AIDS

    160 Hematologic Aspects of Parasitic Diseases

    161 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis

    162 The Spleen and Its Disorders

    163 Hematology in Aging

    164 (Online Only) Resources For The Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations


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