Heart Physiology and Pathophysiology book cover

Heart Physiology and Pathophysiology

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.

: Cardiologists as well as cell biologists, physiologists, pathologists, biophysicists, molecular geneticists, pharmacologists, neuroscientists, haematologists, microbiologists, and molecular biologists. Biomedical researchers and clinicians are likely to want this comprehensive reference.


Published: September 2000

Imprint: Academic Press

ISBN: 978-0-12-656975-9


  • Contributors



    Part I Pumping Action and Electrical Activity of the Heart

    1. Sequence of Cardiac Activation and Ventricular Mechanics

    2. Coronary Circulation and Hemodynamics

    3. Neurohumoral Control of Cardiac Function

    4. Control of Cardiac Output and its Alterations during Exercise and in Heart Failure

    5. Ultrastructure of Cardiac Muscle and Blood Vessels

    6. Excitability and Impulse Propagation

    7. Electrocardiogram and Cardiac Excitation

    8. Gap-Junction Channels and Healing-Over of Injury

    Part II Cellular Electrophysiology of Heart and Vascular Smooth Muscle

    9. Electrogenesis of the Resting Potential

    10. Cardiac Action Potentials

    11. Electrophysiology of Vascular Smooth Muscle

    12. Sodium Channels

    13. Voltage-Dependent Calcium Channels

    14. Voltage-Dependent K+ Channels

    15. Inwardly-Rectifying K+ Channels in the Heart

    16. Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle

    17. Ion Channels in Vascular Smooth Muscle

    18. Cardiac Pacemaker Currents

    19. Chloride Channels in Heart

    20. Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and Stretch


    21. Cardiac Na+/K+ Pump

    22. Cardiac Na+-Ca2+ Exchanger: Pathophysiology and Pharmacology

    23. Na+/H+ Exchanger and pH Regulation

    24. Transport in Nucleus

    25. Sarcoplasmic Reticulum Ca2+ Transport

    26. Calcium Release from Cardiac Sarcoplasmic Reticulum

    Part IV Vascular Endothelium

    27. Function of Vascular Endothelium

    28. Ion Channels in Vascular Endothelium

    Part V Excitation-Contraction Coupling and Pharmacomechanical Coupling

    29. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells

    30. Mechanisms Regulating Cardiac Myofilament Response to Calcium

    31. Vascular Smooth Muscle Contraction

    Part VI Metabolism and Energetics

    32. Myocardial Energy Metabolism

    33. Metabolism and Energetics of Vascular Smooth Muscle

    Part VII Signaling Systems

    34. Adrenergic Receptors in the Cardiovascular System

    35. Cardiac Action of Angiotensin II

    36. ATP and Adenosine Signal Transductions

    37. Kinase Signaling in the Cardiovascular System

    38. Calcium Signaling

    39. Diadenosine Polyphosphate Signaling in the Heart

    Part VIII Developmental Changes and Aging

    40. Cardiac Development and Regulation of Cardiac Transcription

    41. Developmental Changes of Ion Channels

    42. Aging of the Cardiovascular System

    43. Changes in Autonomic Responsiveness during Development

    Part IX Mechanism of Action of Cardioactive Drugs

    44. Inotropic Mechanism in Cardiac Muscle

    45. Mechanisms of Action of Calcium Antagonists

    46. Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation

    47. K+ Channel Openers

    48. Mode of Action of Antiarrhythmic Drugs

    Part X Pathophysiology

    49. Cellular Mechanisms of Cardioprotection

    50. Ischemic Preconditioning: Description, Mechanism, and Significance

    51. Cardioplegia and Surgical Ischemia

    52. Apoptosis

    53. Calcium Overload in Ischemia/Reperfusion Injury

    54. Coronary Atherosclerosis and Restenosis

    55. Diabetic Vascular Disease

    56. Angiogenesis and Coronary Collateral Circulation

    57. Molecular Pathophysiology of Cardiomyopathies

    58. Signal Transduction of Cardiac Myocyte Hypertrophy

    59. Electrophysiological Changes in Hypertrophy

    60. Molecular Basis of Inherited Long QT Syndromes and Cardiac Arrhythmias

    61. Molecular Mechanisms of Atrial Fibrillation

    62. Lipids Released during Ischemia and Arrhythmogenesis

    63. Ion Channels in the Heart

    64. Cardiac Arrhythmias: Reentry and Triggered Activity

    65. Myocardial Reperfusion Injury-Role of Free Radicals and Mediators of Inflammation

    66. Cardiac Toxicology

    67. Regulation of Gene Expression by Hypoxia

    68. Gene Transfer in Cardiovascular Therapy



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