Heart Physiology and Pathophysiology

Edited by

  • Yoshihisa Kurachi, Graduate School of Medicine, Osaka University, Osaka, Japan
  • Andre Terzic, Mayo Clinic and Foundation, Rochester, Minnesota, U.S.A.
  • Michael Cohen, University of South Alabama, College of Medicine, Mobile, U.S.A.


  • Nicholas Sperelakis, University of Cincinnati, Ohio, U.S.A.

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.
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: Cardiologists as well as cell biologists, physiologists, pathologists, biophysicists, molecular geneticists, pharmacologists, neuroscientists, haematologists, microbiologists, and molecular biologists. Biomedical researchers and clinicians are likely to want this comprehensive reference.


Book information

  • Published: September 2000
  • ISBN: 978-0-12-656975-9

Table of Contents




Part I Pumping Action and Electrical Activity of the Heart

1. Sequence of Cardiac Activation and Ventricular Mechanics

2. Coronary Circulation and Hemodynamics

3. Neurohumoral Control of Cardiac Function

4. Control of Cardiac Output and its Alterations during Exercise and in Heart Failure

5. Ultrastructure of Cardiac Muscle and Blood Vessels

6. Excitability and Impulse Propagation

7. Electrocardiogram and Cardiac Excitation

8. Gap-Junction Channels and Healing-Over of Injury

Part II Cellular Electrophysiology of Heart and Vascular Smooth Muscle

9. Electrogenesis of the Resting Potential

10. Cardiac Action Potentials

11. Electrophysiology of Vascular Smooth Muscle

12. Sodium Channels

13. Voltage-Dependent Calcium Channels

14. Voltage-Dependent K+ Channels

15. Inwardly-Rectifying K+ Channels in the Heart

16. Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle

17. Ion Channels in Vascular Smooth Muscle

18. Cardiac Pacemaker Currents

19. Chloride Channels in Heart

20. Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and Stretch


21. Cardiac Na+/K+ Pump

22. Cardiac Na+-Ca2+ Exchanger: Pathophysiology and Pharmacology

23. Na+/H+ Exchanger and pH Regulation

24. Transport in Nucleus

25. Sarcoplasmic Reticulum Ca2+ Transport

26. Calcium Release from Cardiac Sarcoplasmic Reticulum

Part IV Vascular Endothelium

27. Function of Vascular Endothelium

28. Ion Channels in Vascular Endothelium

Part V Excitation-Contraction Coupling and Pharmacomechanical Coupling

29. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells

30. Mechanisms Regulating Cardiac Myofilament Response to Calcium

31. Vascular Smooth Muscle Contraction

Part VI Metabolism and Energetics

32. Myocardial Energy Metabolism

33. Metabolism and Energetics of Vascular Smooth Muscle

Part VII Signaling Systems

34. Adrenergic Receptors in the Cardiovascular System

35. Cardiac Action of Angiotensin II

36. ATP and Adenosine Signal Transductions

37. Kinase Signaling in the Cardiovascular System

38. Calcium Signaling

39. Diadenosine Polyphosphate Signaling in the Heart

Part VIII Developmental Changes and Aging

40. Cardiac Development and Regulation of Cardiac Transcription

41. Developmental Changes of Ion Channels

42. Aging of the Cardiovascular System

43. Changes in Autonomic Responsiveness during Development

Part IX Mechanism of Action of Cardioactive Drugs

44. Inotropic Mechanism in Cardiac Muscle

45. Mechanisms of Action of Calcium Antagonists

46. Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation

47. K+ Channel Openers

48. Mode of Action of Antiarrhythmic Drugs

Part X Pathophysiology

49. Cellular Mechanisms of Cardioprotection

50. Ischemic Preconditioning: Description, Mechanism, and Significance

51. Cardioplegia and Surgical Ischemia

52. Apoptosis

53. Calcium Overload in Ischemia/Reperfusion Injury

54. Coronary Atherosclerosis and Restenosis

55. Diabetic Vascular Disease

56. Angiogenesis and Coronary Collateral Circulation

57. Molecular Pathophysiology of Cardiomyopathies

58. Signal Transduction of Cardiac Myocyte Hypertrophy

59. Electrophysiological Changes in Hypertrophy

60. Molecular Basis of Inherited Long QT Syndromes and Cardiac Arrhythmias

61. Molecular Mechanisms of Atrial Fibrillation

62. Lipids Released during Ischemia and Arrhythmogenesis

63. Ion Channels in the Heart

64. Cardiac Arrhythmias: Reentry and Triggered Activity

65. Myocardial Reperfusion Injury-Role of Free Radicals and Mediators of Inflammation

66. Cardiac Toxicology

67. Regulation of Gene Expression by Hypoxia

68. Gene Transfer in Cardiovascular Therapy