Headache book cover


Handbook of Clinical Neurology Series (Editors: Aminoff, Boller and Swaab)

This volume is about headache disorders, a universal problem for healthcare providers around the globe. It encompasses major developments, including the role of genetics and genomics in the emergence of new fields such as migraine genetics.

Clinicians will find an exhaustive, up-to-date accounting of cultural developments and the scientific advances that have revolutionized the medical community’s understanding of all types of headaches. The value of evidence-based medicine and transitional research is highlighted, along with diagnostic tools that have proven effective in clinical settings.

This handbook provides a comprehensive explanation of the neurobiological aspects of the nervous system in health and disease, as well as the clinical aspects of neurological disease. In addition, the contributions made by the biological sciences to further an understanding of the pathophysiology of headaches are discussed, with critical information on primary and secondary headaches.

Clinical neurologists and neuroscientist with an interest in headache

Hardbound, 856 Pages

Published: September 2010

Imprint: Elsevier

ISBN: 978-0-444-52139-2


  • "This book offers a complete overview and update of the scientific and cultural developments that, since the publication of the previous Handbook on headaches, have revolutionised understanding of migraine and other headaches. This process was made possible by the fact that many of the distinguished authors who contributed to the book have been protagonists in the advancement of headache science in recent decades. The aim of the publishers of this third edition of the Handbook was to provide basic researchers and clinicians with an updated bibliographical resource that would increase all-round knowledge of the various forms of headache and also provide pointers for new lines of research. On reading this book it is clear that Professors Nappi and Moskowitz have accomplished this arduous task. The broad range of different skills and backgrounds (not only geographical but also cultural) of the editors and co-authors of this book not only provide a guarantee of its undisputed scientific quality, but also give it an international dimension."--Functional Neurology 2012; 29(1): 67


  • Section 1: General aspects: 1. Epidemiology of headache. The social impact and burden of headache.

    Section 2: Biological science of headache: Biological sciences related to headache. Pharmacology. Biological science of headache channels. Genetics of headaches. The neurobiology of migraine. Experimental models of migraine.

    Section 3: Management of headache: Management of headache patients. Headache diaries and calendars. Implementing the International Classification of Headache Disorders, 2nd edn (ICHD-II). Triggers of migraine and tension-type headache. Acute headache in the emergency department. Therapeutic guidelines for headache. The role of prevention. Managing migraine associated with sensitization. Botulinum neurotoxin in the treatment of headache disorders. The approach to the difficult patient. Ethical issues in headache management. The role of lay associations.

    Section 4: Primary headache: Migraine: Migraine: general aspects. Pathophysiology of migraine. Migraine – clinical neurophysiology. Migraine: clinical diagnostic criteria. Migraine and reproductive life. Acute treatment of migraine.

    Migraine: preventive treatment.

    Tension-type headache:

    Tension-type headache: introduction and diagnostic criteria. Tension-type headache: mechanisms. The clinical neurophysiology of tension-type headache. Treatment of tension-type headache.

    Cluster headache and trigeminal autonomic cephalalgias:

    Cluster headache and trigeminal autonomic cephalalgias: general aspects. Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias. Neuroimaging and clinical neurophysiology in cluster headache and trigeminal autonomic cephalalgias. Cluster headache and other trigeminal autonomic cephalalgias: diagnostic criteria. Preventive treatment of cluster headache and other trigeminal autonomic cephalalgias. Neurostimulation therapy in intractable headaches.

    Other primary headache:

    Other primary headache – general aspects. Primary stabbing headache. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity. Hypnic headache. Primary thunderclap headache. Hemicrania continua. New daily persistent headache.

    Section 5: Secondary headache:

    Secondary headaches: introduction. Headache attributed to head or neck trauma. Headache attributed to stroke, TIA, intracerebral haemorrhage, or vascular malformation. Headache attributed to arteritis, cerebral venous thrombosis, and other vascular intracranial disturbances. Headache attributed to carotid or vertebral artery pain. Headache attributed to non-vascular intracranial disorder. Headache attributed to a substance or its withdrawal. Headache attributed to infections: nosography and differential diagnosis. Headache attributed to disorders of homeostasis. Headache or facial pain attributed to disorders of cranium, neck, eyes, ears, nose, sinuses, teeth, mouth, or other facial or cranial structures. Headache attributed to psychiatric disorders. Cranial neuralgias. Surgical treatment of cranial neuralgias. Central pain in the face and head.

    Section 6: Special issues:

    Chronobiological correlates of primary headaches. Headache: endocrinological aspects. Headache in children. Migraine vertigo (vestibular migraine). Pharmacological migraine provocation: a human model of migraine. Neuroimaging in headache. Current and emerging therapies for migraine prevention and treatment.


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