Handbook of Systems Biology book cover

Handbook of Systems Biology

Concepts and Insights

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.

Audience

Current researchers and recent graduates in genetics, molecular biology, cell biology, biomedical science, and systems engineering who can integrate systems biology concepts into their work

Hardbound, 552 Pages

Published: November 2012

Imprint: Academic Press

ISBN: 978-0-12-385944-0

Reviews

  • "Systems biology is a field concerned with the interactions of biomolecules, tissues, and organs amongst each other. This work is essentially an introductory textbook for this field as well as a reference for scientists working in it. Editors Walhout and Dekker are systems biologists, while Vidal is a geneticist. They bring together numerous contributors with backgrounds ranging from physics to various biological specialties."--Reference & Research Book News, December 2013
    "This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work."--Doody.com, April 24, 2013


Contents

  • SECTION I: Component of biological systems
    Proteomic analysis of cellular systems
    The protein-coding transcriptome
    ncRNAs and their targets

    SECTION II: Network properties of biological systems
    Probabilistic functional networks
    Protein-protein inteactome networks
    Gene regulatory networks
    Phenotypic profiling networks
    Genetic interaction networks
    Chromatin networks
    Drug-target networks
    Graph theory properties of cellular networks

    SECTION III: Dynamic and logical propoerties of biological systems
    Boolean models of cellular networks
    Bayesian approaches in understanding networks
    Transcriptional network logic in development
    Metabolic systems reconstruction
    Evolution of biological networks
    Systems understanding of the cell cycle
    Quantitative design principles on molecular systems
    Systems biology of signaling
    Single cell systems dynamics
    Spatial organization of cellular systems

    SECTION IV: Systems and biology
    Systems understanding of yeast biology
    systems understandingof c.elegans development
    Biological systems in Arabidopsis
    Biological rhythms in development and hemeostasis
    System biology of stem cells
    The brain connectome

    SECTION V:MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY
    Systems medicine
    Cancer systems biology
    Infectious disease and the immune system
    Network perturbations and disease states
    Impact of personal genomics on systems biology
    Social networks, human disease, and epidemics

Advertisement

advert image