Handbook of Systems Biology

Concepts and Insights

Edited by

  • Marian Walhout, UMass Medical School, Worcester, MA
  • Marc Vidal, Dana-Farber Cancer Institute, Boston, MA,and Harvard Medical School, Cambridge, MA
  • Job Dekker, University of Massachusetts Medical School, Worcester, MA

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.
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Audience

Current researchers and recent graduates in genetics, molecular biology, cell biology, biomedical science, and systems engineering who can integrate systems biology concepts into their work

 

Book information

  • Published: November 2012
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-385944-0

Reviews

"Systems biology is a field concerned with the interactions of biomolecules, tissues, and organs amongst each other. This work is essentially an introductory textbook for this field as well as a reference for scientists working in it. Editors Walhout and Dekker are systems biologists, while Vidal is a geneticist. They bring together numerous contributors with backgrounds ranging from physics to various biological specialties."--Reference & Research Book News, December 2013
"This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work."--Doody.com, April 24, 2013




Table of Contents

SECTION I: Component of biological systems
Proteomic analysis of cellular systems
The protein-coding transcriptome
ncRNAs and their targets

SECTION II: Network properties of biological systems
Probabilistic functional networks
Protein-protein inteactome networks
Gene regulatory networks
Phenotypic profiling networks
Genetic interaction networks
Chromatin networks
Drug-target networks
Graph theory properties of cellular networks

SECTION III: Dynamic and logical propoerties of biological systems
Boolean models of cellular networks
Bayesian approaches in understanding networks
Transcriptional network logic in development
Metabolic systems reconstruction
Evolution of biological networks
Systems understanding of the cell cycle
Quantitative design principles on molecular systems
Systems biology of signaling
Single cell systems dynamics
Spatial organization of cellular systems

SECTION IV: Systems and biology
Systems understanding of yeast biology
systems understandingof c.elegans development
Biological systems in Arabidopsis
Biological rhythms in development and hemeostasis
System biology of stem cells
The brain connectome

SECTION V:MULTISCALE BIOLOGICAL SYSTEMS, HEALTH AND ECOLOGY
Systems medicine
Cancer systems biology
Infectious disease and the immune system
Network perturbations and disease states
Impact of personal genomics on systems biology
Social networks, human disease, and epidemics