Handbook of Pharmacogenomics and Stratified Medicine book cover

Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

Audience

Clinical researchers across medical disciplines, genetics, molecular biology, molecular diagnostics, and genomic studies who are working on the various aspects of translational genetics and genomics; pharmacologists working with clinicians on these studies

Hardbound, 1118 Pages

Published: May 2014

Imprint: Academic Press

ISBN: 978-0-12-386882-4

Contents

  • Introduction
    1.  Pharmacogenomics and Stratified Medicine

    Basic Genetics
    2. Basic Genetics - Cell, Mitosis, Meiosis, and Mendelian laws
    3. Human Genome, Genomic Variation and Gene Regulation
    4. Epigenetics

    Experimental and discovery platforms
    5. Animal Models in Pharmacogenomics
    6. Human Lymphoblastoid Cell Lines in Pharmacogenomics
    7. Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches to Interpret and Inform Pharmacogenomic Studies
    8. Next Gen Sequencing
    9. Proteomics
    10. Metabolomics
    11. Stem Cells

    Statistics, Bioinformatics and Databases
    12. Fundamentals of Complex Trait Genetics and Association Studies
    13. Bioinformatics - Concepts, Methods and Data
    14. PharmGKB: The Pharmacogenomics Knowledgebase

    Clinical Trials
    15. Clinical Trials

    Fundamental Pharmacogenomics
    16. CYP450 and Ethnicity
    17. Pharmacokinetic Pharmacogenetics
    18. Pharmacodynamic Pharmacogenetics
    19. MicroRNA - Regulation of P450 and Pharmacogenetics

    Applications in Therapeutics
    20. Adverse Drug Reactions
    21. HLA and the Pharmacogenomics of Drug Hypersensitivity
    22. Drug Induced Liver Injury
    23. Haemostasis and Anticoagulants
    24. Pharmacogenomics of Warfarin
    25. Pharmacogenomics of Clopidogrel
    26. Pharmacogenetics of Antidepressant Drugs
    27. Personalized Medicine of Alzheimer’s disease
    28. Asthma
    29. Rheumatoid Arthritis
    30. Pharmacogenomics of Oral Antidiabetic Drugs
    31. Genomics and Pharmacogenomics of Lipid Lowering Therapies
    32. Hypertension Pharmacogenomics
    33. QTc and Sudden Cardiac Death
    34. Stratified Medicine for Pancreatic Cancer
    35. Pharmacogenomics in Anaesthesia
    36. Tuberculosis
    37. Hepatitis C Virus
    38. Pharmacogenomics of Antifungal Agents
    39. Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites


    Implementation and Regulatory
    40. Implementing Clinical Pharmacogenetics: Point-of-care and Pre-emptive Testing
    41. Ethical Considerations for Pharmacogenomic Testing in Paediatrics
    42. PGx/biomarker Utilization for Regulatory Decision Making

    Global Perspective
    43. Population Diversity and Pharmacogenomics in Africa
    44. Pharmacogenomics in China
    45. Pharmacogenomics in Brazil
    46. Pharmacogenomics in India

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