Handbook of Pharmacogenomics and Stratified Medicine

Editor-in-Chief:

  • Sandosh Padmanabhan, Clinical Senior Lecturer, Institute of Cardiovascular and Medical Sciences; College of Medical, Veterinary and Life Sciences; University of Glasgow; UK

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

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Audience

Clinical researchers across medical disciplines, genetics, molecular biology, molecular diagnostics, and genomic studies who are working on the various aspects of translational genetics and genomics; pharmacologists working with clinicians on these studies

 

Book information

  • Published: May 2014
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-386882-4

Reviews

"…a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time."--Anticancer Research, January 2015

"This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. - Rating: 5 Stars"--Doody's.com, 03-Oct-14




Table of Contents

Introduction
1.  Pharmacogenomics and Stratified Medicine

Basic Genetics
2. Basic Genetics - Cell, Mitosis, Meiosis, and Mendelian laws
3. Human Genome, Genomic Variation and Gene Regulation
4. Epigenetics

Experimental and discovery platforms
5. Animal Models in Pharmacogenomics
6. Human Lymphoblastoid Cell Lines in Pharmacogenomics
7. Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches to Interpret and Inform Pharmacogenomic Studies
8. Next Gen Sequencing
9. Proteomics
10. Metabolomics
11. Stem Cells

Statistics, Bioinformatics and Databases
12. Fundamentals of Complex Trait Genetics and Association Studies
13. Bioinformatics - Concepts, Methods and Data
14. PharmGKB: The Pharmacogenomics Knowledgebase

Clinical Trials
15. Clinical Trials

Fundamental Pharmacogenomics
16. CYP450 and Ethnicity
17. Pharmacokinetic Pharmacogenetics
18. Pharmacodynamic Pharmacogenetics
19. MicroRNA - Regulation of P450 and Pharmacogenetics

Applications in Therapeutics
20. Adverse Drug Reactions
21. HLA and the Pharmacogenomics of Drug Hypersensitivity
22. Drug Induced Liver Injury
23. Haemostasis and Anticoagulants
24. Pharmacogenomics of Warfarin
25. Pharmacogenomics of Clopidogrel
26. Pharmacogenetics of Antidepressant Drugs
27. Personalized Medicine of Alzheimer’s disease
28. Asthma
29. Rheumatoid Arthritis
30. Pharmacogenomics of Oral Antidiabetic Drugs
31. Genomics and Pharmacogenomics of Lipid Lowering Therapies
32. Hypertension Pharmacogenomics
33. QTc and Sudden Cardiac Death
34. Stratified Medicine for Pancreatic Cancer
35. Pharmacogenomics in Anaesthesia
36. Tuberculosis
37. Hepatitis C Virus
38. Pharmacogenomics of Antifungal Agents
39. Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites


Implementation and Regulatory
40. Implementing Clinical Pharmacogenetics: Point-of-care and Pre-emptive Testing
41. Ethical Considerations for Pharmacogenomic Testing in Paediatrics
42. PGx/biomarker Utilization for Regulatory Decision Making

Global Perspective
43. Population Diversity and Pharmacogenomics in Africa
44. Pharmacogenomics in China
45. Pharmacogenomics in Brazil
46. Pharmacogenomics in India