Handbook of Models for Human Aging

  • Stephen Benjamin
    • Caleb Finch, University of Southern California, Los Angeles, CA, USA
      • John Guerin
        • James Nelson
          • S. Jay Olshansky
            • George Roth
              • Roy Smith
              • Edited by

                • P. Michael Conn, Texas Tech University Health Sciences Center, Lubbock, USA

                This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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                Researchers interested in the mechanisms of aging, gerontologists, health professionals, and allied health professionals and students


Book information

  • Published: February 2006
  • ISBN: 978-0-12-369391-4


"Taken all together, this handbook gives an excellent impression of what is done in aging research nowadays, which models are applied for which question and where the limitations of the models are. It covers very broadly standard models as well as more exotic, just emerging modles of aging research. Michael Conn has indeed achieved his goal of creating a comprehensive handbook covering all models of research." - Martina Rauner in WIENER MEDIZINISCHE WOCHENSCHRIFT

Table of Contents

I. Introduction1. Historical Development of Animal Models of AgingRichard L Sprott, Steven N Austad2. Species Selection in Comparative Studies of Aging and Anti-AgingJoao Pedro de Magalhaes3. Principles of Animal Use for Gerontological ResearchRichard A. Miller4. From Primary Cultures to the Aging Organism: Lessons from Human T LymphocytesRita B Effros5. Models of Systems Failure in AgingLeonid A Gavrilov, Natalia S. Gavrilova6. Major Issues in Ethics of Aging ResearchMichael D Smith7. Ethical Aspects of Research Involving Elderly PersonsPaul S Mueller, C. Christopher HookII. General Methods8. SAGE KE and Other Online Resources Related to AgingEvelyn Strauss, R. John Davenport9. Proteomics in Aging ResearchChristian Schoneich10. Application of High-throughput Technologies to Aging-related ResearchMatt Kaeberlein11. Models of Alzheimer's DiseaseHarry LeVine, III, Lary C Walker12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal AgingScott A Small13. Epidemiology in Aging ResearchHermann Brenner, Volker Arndt14. Statistical Issues for Longevity Studies in Animal ModelsChenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison15. Models for the Study of Infection in PopulationsJohn R Williams16. Estimation of the rate of production of oxygen radicals at mitochondriaAlberto Sanz, Gustavo BarjaIII. Animal ModelsA. Premammalian Systems17. Telomeres and Aging in the Yeast Model SystemKurt W Runge18. Longevity and Aging in the Budding YeastMatt Kaeberlein19. From Yeast Methuselah Genes to Evolutionary MedicinePaolo Fabrizio, Valter D. Longo20. Strongyloides Ratti: A Nematode with Extraordinary Plasticity in AgingMichael P. Gardner, David Gems, Mark Viney21. Insect Models for the Study of AgingKlaus-Guenter Collatz22. Drosophila Models of AgingSatomi Miwa, Alan Cohen23. Models of Aging in Honeybee WorkersGro V Amdam, Olav Rueppel24. Ants as Naturally Long-lived Insect Models for AgingJoel D Parker, Karen M ParkerB. Mammalian Systems25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogasterRobert Arking26. Annual Fish as a Genetic Model for AgingPudur Jagadeeswaran27. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and DiseaseEvan T Keller, Jill M. Keller, Gavin Gillespie28. Zebrafish as Aging ModelsShuji Kishi29. Telomeres In Aging: BirdsSusan E. Swanberg, Mary E. Delany30. Domestic and Wild Bird Models for the Study of AgingDonna J. Holmes, M.A. Ottinger31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie RestrictionIsao Shimokawa32. Rat Models of Age-related Cognitive DeclineJennifer L Bizon, Michelle M Nicolle33. Aged Rodents for Biogerontology ResearchNancy L. Nadon34. Life Extension in the Dwarf MouseAndrzej Bartke35. The Canine Model of Human Brain Aging: Cognition, Behavior, and NeuropathologyP Dwight Tapp, Christina T Siwak36. Bats as a Novel Model for Aging ResearchAnja K Brunet-Rossinni, Rocco E. Rossinni37. Memory in the Aging Hippocampus: What can place cells tell us?Iain A Wilson38. The Rhesus Macaque as a Model of Human Aging and Age-Related DiseaseMary Ann Ottinger, Jullie A. Mattison; Mary B. Zelinski, Julie M. Wu, Steve Kohama, George S. Roth, Mark A. Lane, Donald K. Ingram39. Non-human Primates as a Model for Reproductinve Aging and Human InfertilityBarry D. Bavister, Carol A. BrennerIV. Comparative Models40. Neurobiology of the Aging BrainCarlo Bertoni-Freddari, Patrizia Fattoretti, William Meier-Ruge41. Mitochondrial DNA and AgingMikhail Alexeyev, Susan P. LeDoux, Glen L. Wilson42. Models for ApoptosisChristiane Charriaut-Marlangue, Sylvain Renolleau43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive SenescenceJacqueline A. Maffucci, Andrea C. Gore44. Models of Chaperones in AgingJens Kroll, J. O. Nehlin45. Therapeutic Potential of Stem Cells In Aging Related DiseasesShannon Whirledge, Kirk C.L. Lo, and Dolores J. Lamb46. Nuclear Transfer and Cloning: Preservaton or Expansion of Proliferative Lifespan?Keith E Latham47. Human Models of LongevityThomas Perls48. Computational Models of Mitochondrial DNA in AgingDavid C Samuels49. Mouse Models of Accelerated AgingJan Vijg, Paul HastyV. Disease-States and Normal AgingA. Disease States50. Models, Definitions, and Criteria of FrailtyDavid B. Hogan51. Fertility and Aging MenPeter N Schlegel, Puneet Masson, Sarah M. Lambert, Harry Fisch52. Benign Prostatic HyperplasiaPeter N Celec53. Murine Models of Infectious Diseases in the AgedKevin P High54. Physiopathology, clinical symptoms and causative agents of pneumoniaJean-Paul Janssens55. Diabetes and AgingTamas Fulop, A. Larbi; D. Tessier, A. Carpentier56. Diabetes as a Model of Premature AgingArshag D Mooradian57. Frailty as a Model of AgingJeremy D. Walston58. Osteoporosis and Cardiovascular Disease in the ElderlySamy I McFarlane, MD, FACP, FACE, CCD, John Nicasio, Ranganath Muniyappa59. Depression in Older PatientsKiran Rabheru60. The Aging Human Lung: Age-associated Changes in Structure and FunctionKeith C. Meyer61. Iceland as a Model for Human AgingAdalsteinn Gudmundsson, Palmi V Jonsson62. Behavior and Personality in the Study of Successful AgingJudith Corr, Lorraine TarouB. Health Issues Affecting the Elderly63. AndropauseRabih Hijazi, Glenn R. Cunningham*64. Aging and the perceptual organization of sounds: a change of scene?Claude Alain, Benjamin J. Dyson, Joel S. Snyder65. Models of Immune Function in AgingChristopher A. Jolly, Zhun Xu66. Human T Cell Clones in Long-term Culture as Models for the Impact of Chronic Antigenic Stress in AgingGraham Pawelec, Erminia Mariani, Rafael Solana, Rosalyn Forsey, Anis Larbi, Simone Neri, Olga Dela Rosa, Yvonne Barnett, Jon Tolson, Tamas Fulop67. Age-Related Changes in the Human RetinaCarlo Cavallotti, Nicola Pescosolido68. Models of Age Related Vision ProblemsJ. Fielding Hejtmancik, Mark Kantorow, Takeshi Iwata69. Health, Functional and Therapeutic Implications of Obesity in AgingR L Kennedy, E Y H Khoo70. Age and JointsKlaus Bobacz, Ilse-Gerlinde Sunk71. Sleep Quality in the ElderlyRagnar Asplund72. Atherogenesis and AgingCam Patterson73. Managing Menopausal SymptonsMary Ellen Rousseau74. Psychological Aging: A Contextual ViewHans-Werner Wahl, Frieder R. Lang75. Nutrients and AgingLawrence J WhalleyC. Approaches to Treatment and Models76. Methods for Studying Hearing Impairment and Auditory Problems of the AgedRobert D Frisina, D. Robert Frisina77. A Model for Understanding the Pathomechanics of Osteoarthritis in AgingThomas P Andriacchi, Annegret Mundermann78. Aging and Cardiovascular Angiogenesis ModelsAndrew Chin, Jacquelyn M. Holm, Inga J. Duignan, and Jay M. Edelberg*79. Models for the Study of StrokeThiruma V. Arumugam, Mark P. Mattson*80. Werner Syndrome as a Model of Human AgingRaymond J Monnat, Jr81. Models of SarcopeniaAlfred L Fisher82. Aging of Human SkinPaolo U Giacomoni83. Models of Hypertension in AgingJane F Reckelhoff, Radu Iliescu, Licy Yanes, Lourdes A Fortepiani