Handbook of Developmental Neurotoxicology


  • William Slikker, Jr., National Center for Toxicological Research, Jefferson, Arkansas, U.S.A.
  • William Slikker, Jr., National Center for Toxicological Research, Jefferson, Arkansas, U.S.A.
  • Louis Chang, University of Arkansas, Little Rock, U.S.A.

The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology.
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Researchers and students in toxicology, developmental biology, pharmacology, and neuroscience.


Book information

  • Published: July 1998
  • ISBN: 978-0-12-648860-9

Table of Contents

Cellular and Molecular Morphogenesis:K. Jensen, Brain Morphogenesis and Developmental Neurotoxicology.G.B. Grunwald, Cadherin Cell Adhesion Molecules in Normal and Abnormal Neural Development.G. Audesirk and T. Audesirk, Neurocytoskeleton and Neuritic Development.G.J. Harry and A.D. Toews, Myelination, Dysmyelination, and Demyelination.Developmental Biology/Toxicology:R.M. Greene, W. Weston, P. Nugent, M. Potchinsky, and M.M. Pisano, Signal Transduction Pathways as Targets for Induced Embryotoxicity.M.V. Chao, H. Kong, S.O. Yoon, B. Carter, and P. C.-Bonnefil, Trophic Nerve Growth Factors.J.M. Lauder and J. Liu, Neurotoxic and Neurotrophic Effects of GABAergic Agents on Developing Neurotransmitter Systems.P.E. Mirkes and M.A. Shield, Apoptosis.J.F. Grippo, Receptor Mediated.R.H. Finnell and G.D. Bennett, The Periods of Susceptibility to Induced Malformations of the Developing Mammalian Brain.T.B. Knudsen and J.A. Wubah, Transgenic Animal Models. Synaptogenesis and Neurotransmission:A.G. Hendrickx and P.E. Peterson, Neural Crest Cell Migration.H.W. Broening and W. Slikker, Ontogeny of Neurotransmitters: Monoamines.D.A. Jett, Central Cholinergic Neurobiology.L.G. Costa, Ontogeny of Second Messenger Systems.T.R. Guilarte, The N-Methyl-D-Aspartate Receptor: Physiology and Neurotoxicology in the Developing Brain.Nutrient and Chemical Disposition:R.K. Miller, Placental Transfer.M.R. Juchau and H. Chen, Developmental Enzymology: Xenobiotic Biotransformation.E.J. O'Flaherty, PB/PK Models.M.L. Bogle, Nutrition Postnatal Adult.C.L. Keen, Nutrition, Chemistry and Genetics.M. Aschner, Blood-Brain Barrier: Physiological and Functional Considerations.S.F. Ali and S. Hussain, Antioxidant Enzymes: Developmental Profiles and their Role in Metal-Induced Oxidative Stress.J.E. Polifka, Drug and Chemical Components in Breast Milk: Effects on Neurodevelopment of the Nursing Infant.Behavioral Assessment:J.H. Hannigan, Normal Development and Susceptibility.J.S. Meyer, Behavioral Assessment in Developmental Neurotoxicology: Approaches Involving Unconditioned Behaviors and Pharmacological Challenges in Rodents.M.E. Stanton and D. Frederick, Assessment of Behavior/Rodents/Learning Tasks.M.G. Paule, Assessment of Behavior--Primates.Clinical Assessment and Epidemiology:A. van Baar, Evaluation of the Human Newborn Infant.C. Coles and J.A. Kable, Developmental Evaluation of the Older Infant and Child.P.A. Fried, Behavioral Evaluation of the Older Infant and Child.N.L. Day and G.A. Richardson, Epidemiological Studies of the Effects of Prenatal Cocaine Exposure on Child Development and Behavior.J.M. Friedman, Assessment of Case Reports and Clinical Series. Specific Neurotoxic Syndromes:G. Koren, B. O'Hayon, J. Gladstone, and I. Nulman, Fetal Alcohol Syndrome.L.W. Chang and G.L. Guo, Fetal Minamata Disease.L. Hastings and M.L. Miller, Developmental Neurotoxicology of Cadmium.D.C. Rice, Developmental Lead Exposure: Neurobehavioral Consequences.M.G. Paule, Maternal Drug Abuse.D. Desaiah, Developmental Toxicity of Pesticides.E.D. Levin and T.A. Slotkin, Developmental Neurotoxicity of Nicotine.J. Adams and R.R. Holson, Vitamin A Analogs.D.K. Hansen and R.R. Holson, Developmental Neurotoxicity of Antiepileptic Drugs.P.M. Rodier, Neuroteratology of Autism.Risk Assessment:C.A. Kimmel, Current Approaches.J.L. Schardein, Animal/Human Concordance.M. Anderson and K. Krishnan, PB/PK Models.D. Gaylor and W. Slikker, Jr., Quantitative Models.Subject Index.