Handbook of Biologically Active Peptides

Edited by

  • Abba Kastin, Pennington Biomedical Research Center, Baton Rouge, LA, USA
  • Abba Kastin, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.
View full description


Peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists


Book information

  • Published: August 2006
  • ISBN: 978-0-12-369442-3

Table of Contents

Contributors PrefaceForewordI: Plant Peptides Section1. 4-kDa Peptide2. AtPep1 Peptides3. CLAVATA3: A Putative Peptide Ligand Controlling Arabidopsis StemCell4. DVL Peptides Are Involved in Plant Development5. The POLARIS Peptide6. Phytosulfokine7. RALF Peptides8. ROTUNDIFOLIA4: A Plant-Specifi c Small Peptide9. The S-Locus Cysteine-Rich Peptide SCR/SP1110. SysteminsII: Bacterial/Antibiotic Peptides Section11. Cationic Antimicrobial Peptides¬°XThe Defensins12. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides13. Microcins14. Peptaibols15. Nonribosomally Synthesized Microbial Macrocyclic Peptides16. Lantibiotics17. The Nonlantibiotic Heat-Stable Bacteriocins in Gram-Positive Bacteria18. Colicins: Bacterial/Antibiotic PeptidesIII: Fungal/Antifungal Peptides Section19. Fungal Peptides with Antifungal Activity20. Toxins from Basidiomycete Fungi (Mushroom): Amatoxins, Phallotoxins, and Virotoxins21. Fungal Peptides with Ribonuclease Activity22. Fungal Ribosome Inactivating Proteins23. Peptides and Depsipeptides from Plant Pathogenic FungiIV: Invertebrate Peptides Section24. Insect Diuretic and Antidiuretic Hormones25. Developmental Peptides: ETH, Corazonin, and PTTH26. Tachykinins and Tachykinin-Related Peptides in Invertebrates27. Proctolin in Insects28. Sulfakinins29. The Invertebrate AKH/RPCH Family30. Insect Myosuppressins/FMRFamides and FL/IRFamides/NPFs31. Allatostatins in the Insects32. The FXPRLamide (Pyrokinin/PBAN) Peptide Family33. Insect Pigment Dispersing Factor and Bursicon34. Crustacean Bioactive Peptides35. Crustacean Chromatophorotrophins and Hyperglycemic Hormone Peptide Families36. Molluscan Bioactive Peptides37. Molluscan Peptides and Reproduction38. Free-Living Nematode Peptides39. Parasitic Nematode PeptidesV: Amphibian Peptides Section40. Amphibian Tachykinins41. Opioid Peptides from Frog Skin and Bv8-Related Peptides42. Amphibian Bombesin-Like Peptides43. Host Defense Peptides from Australian Amphibians: Caerulein and Other Neuropeptides44. Bradykinin-Related Peptides from Frog Skin45. The Dermaseptins46. The Temporins47. Chromogranins/Secretogranins and Derived Peptides: Insights from the Amphibian Model48. Sodefrin and Related Pheromones49. Amphibian Neurohypophysial Peptides50. BombininsVI: Venom Peptides Section51. Scorpion Venom Peptides52. Snake Venom Peptides53. Sea Anemone Venom Peptides54. Spider Venom Peptides55. Conus Snail Venom Peptides56. Insect Venom Peptides57. Worm Venom Peptides58. Targets and Therapeutic Properties of Venom Peptides59. Structure-Function Strategies to Improve the Pharmacological Value of Animal ToxinsVII: Cancer/Anticancer Peptides Section60. Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Cancer61. Bombesin-Related Peptides and Neurotensin: Effects on Cancer Growth/Proliferation and Cellular Signaling in Cancer62. Somatostatin and NPY63. Bradykinin and Cancer64. Endothelin65. Adrenomedullin: An Esoteric Juggernaut of Human Cancers66. Angiotensin Peptides and Cancer67. Gastrin and Cancer68. VIP and PACAP as Autocrine Growth Factors in Breast and Lung Cancer69. Oxytocin and Cancer70. Antagonists of Growth Hormone¬°VReleasing Hormone (GHRH) in CancerVIII: Vaccine Peptides Section71. Cancer Immunotherapy with Rationally Designed Synthetic Peptides72. Peptide Vaccines for Cancer Treatment73. Antiadhesin Synthetic Peptide Consensus Sequence Vaccine and Antibody Therapeutic for Pseudomonas Aeruginosa74. Peptide Vaccines for Malaria75. Peptide Vaccine for Otitis Media76. Peptide Vaccine for Alzheimer¬°¬¶s Disease77. Peptide Dendrimers as ImmunogensIX: Immunological and Infl ammatory Peptides Section78. Chemotactic Peptide Ligands for Formylpeptide Receptors Influencing Inflammation79. Complement-Derived Inflammatory Peptides: Anaphylatoxins80. Chemokines: A New Peptide Family of Neuromodulators81. Immune Peptides Related to Dipeptidyl Aminopeptidase IV/CD2682. RGD-Peptides and Some Immunological Problems83. Neuropeptides That Regulate Immune Responses84. Peptides as Targets of T Cell-Mediated Immune Responses85. The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries to Identify Immunological Relevant Peptides86. Copolymer 1 and Related Peptides as Immunomodulating Agents87. CLIP¬°XA Multifunctional MHC Class II¬°VAssociated Self-PeptideX: Brain Peptides Section88. Vasopressin and Oxytocin89. Thyrotrophin-Releasing Hormone: New Functions for an Ancient Peptide90. Gonadotrophin Releasing Hormone91. Brain Somatostatin-Related Peptides92. Corticotrophin-Releasing Hormone (CRH) Peptide Family93. Growth Hormone-Releasing Hormone94. PACAP/VIP95. Neuropeptide Y96. Melanocortins97. Cocaine- and Amphetamine-Regulated Transcript (CART)98. The Melanin-Concentrating Hormone99. CCK/Gastrin100. The Hypocretins (Orexins)101. Ghrelin102. Neurotensin103. Neuromedin U (NMU): Brain Peptide104. Galanin and GALP Systems in Brain¬°XMolecular Pharmacology, Anatomy, and Putative Roles in Physiology and Pathology105. Brain Tachykinins106. CGRP and Adrenomedullin in the Brain107. The RFamide-Related Peptides108. Apelin: Discovery, Distribution, and Physiological Role109. Urotensin II and Urotensin II¬°VRelated Peptide110. Brain/B-Type Natriuretic Peptide (BNP) and C-Type Natriuretic Peptide (CNP)111. Endozepines112. KiSS-1/MetastinXI: Endocrine Peptides Section113. Role of Opioid Peptides in the Local Regulation of Endocrine Glands114. Role of Tachykinin-Gene-Related Peptides in the Local Regulation of Endocrine Glands115. Neuropeptide Y and the Regulation of Endocrine Function116. Effects of PACAP in the Local Regulation of Endocrine Glands117. Endothelins in the Local Regulation of Endocrine Glands118. Adrenomedullin and Related Peptides in the Local Regulation of Endocrine Glands119. Ghrelin in the Local Regulation of Endocrine Glands120. Atrial Natriuretic Peptide in Local Regulation of Endocrine Glands121. Galanin, Neurotensin, and Neuromedins in the Local Regulation of Endocrine GlandsXII: Ingestive Peptides Section122. Neuropeptide Y: A Conductor of the Appetite-Regulating Orchestra in the Hypothalamus123. Hypothalamic Galanin and Ingestive Behavior: Relation to Dietary Fat, Alcohol, and Circulating Lipids124. Effects of Melanocortins on Ingestive Behavior125. CART Peptide and Ingestive Behavior126. Orexins and Opioids in Feeding Behavior127. Melanin-Concentrating Hormone128. Corticotrophin-Releasing Hormone (CRH) and Ingestive Behavior129. Peptide YY (PYY) and Neuromedin U (NMU): Effects on Ingestive Behavior130. Ghrelin and Ingestive Behavior131. Cholecystokinin and Satiety132. Enterostatin, a Peptide Regulator of Dietary Fat Ingestion133. Regulation of Feeding Behavior by Glucagonlike Peptide 1 (GLP-1)134. Role of Amylin and Calcitonin-Gene-Related Peptide (CGRP) in the Control of Food Intake135. Leptin and the Regulation of Feeding136. Ingestive Peptides: InsulinXIII: Gastrointestinal Peptides Section137. Adrenomedullin in Gastrointestinal Function138. Calcitonin Gene-Related Peptide and Gastrointestinal Function139. Peripheral Cholecystokinin140. Corticotrophin-Releasing Hormone (CRH) Family in the Gastrointestinal System141. Paneth Cell ‚Äě¬ī-Defensins142. Galanin in the Gastrointestinal Tract: Distribution and Function143. Gastrin144. Gastrin-Releasing Peptide145. Glucagonlike Peptides 1 and 2, Enteroglucagon, Glicentin, and Oxyntomodulin146. Ghrelin147. Leptin and the Gastrointestinal Tract148. Motilin149. Neurotensin in Regulation of Gastrointestinal Functions150. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)151. Pancreatic Polypeptide152. Peptide YY153. Secretin154. Somatostatin155. Somatostatin Analogs in the Gastrointestinal Tract156. Substance P and Related Tachykinins in the Gastrointestinal Tract157. TFF (Trefoil Factor Family) Peptides158. Signaling by Vasoactive Intestinal Peptide in Gastrointestinal Smooth MuscleXIV: Cardiovascular Peptides Section159. Adrenomedullin and Its Related Peptides160. Angiotensin II and Its Related Peptides161. Bradykinin and Its Related Peptides162. Calcitonin Gene-Related Peptides163. Endothelins164. Ghrelin: Its Therapeutic Potential in Heart Failure165. Natriuretic Peptides in the Cardiovascular System166. Urotensin and Its Related Peptides167. Vasoactive Intestinal Peptide168. Cardiovascular Peptides: VasopressinXV: Renal Peptides Section169. Renal Effects of Neurohypophyseal Peptides170. Renal Renin-Angiotensin System171. Renal Natriuretic Peptide System and Actions of Urodilatin172. ANP and Its Role in the Regulation of Renal Tubular Transport Processes173. Adrenomedullin as a Renal Peptide174. Adrenomedullin 2/Intermedin175. Renal Endothelin176. Prolactin and Kidney FunctionXVI: Respiratory Peptides Section177. Therapeutic Potential of Adrenomedullin for Pulmonary Hypertension178. Endothelin in the Airways179. PACAP¬°¬¶s Role in Pulmonary Function180. Tachykinins and Their Receptors in the Lung181. Vasoactive Intestinal PeptideXVII: Opioid Peptides Section182. Proenkephalin-Derived Opioid Peptides183. Prodynorphin-Derived Opioid Peptides184. POMC Opioid Peptides185. Endomorphins as Endogenous Peptides for ‚Äěf-Opioid Receptor: Their Differences in the Pharmacological and Physiological Characters186. Casomorphins and Hemorphins¬°XOpioid Active Peptides Released by Partial Hydrolysis of Structural Proteins187. Anti-Opioid Peptides188. Nociceptin189. Role of Tachykinins in Spinal Nociceptive Mechanisms and Their Interactions with Opioids190. Exorphin-Opioid Active Peptides of Exogenous Origin191. Opioid-Substance P Chimeric PeptidesXVIII: Neurotrophic Peptides Section192. VIP- and PACAP-Related Neuroprotection193. Insulin-Like Growth Factor 1194. Erythropoietin¬°XA Hematopoietic Hormone with Emerging Diverse Activities195. Neuregulins196. The NeurotrophinsXIX: Blood-Brain Barrier Peptides Section197. Amino Acid Transport Across the Blood¬°VBrain Barrier198. Oligopeptide Transport at the Blood¬°VBrain and Blood¬°VCSF Barriers199. Opiate Peptides and the Blood¬°VBrain Barrier200. Permeability of the Blood¬°VBrain Barrier to Neurotrophic Peptides201. Transport of Basic Peptides at the Blood¬°VBrain Barrier202. Fibroblast Growth Factor and the Blood¬°VBrain Barrier203. Ingestive Peptides and the Blood¬°VBrain Barrier 204. Functional Aspects of Vasoactive Peptides at the Blood¬°VBrain Barrier205. Hypothalamic Neuropeptides and the Blood¬°VBrain Barrier206. Diseases Mediated by the BBB: From Alzheimer¬°¬¶s to ObesityXX: Other Peptide Topics207. Prebiotic Peptides208. Mixture-Based Combinatorial Libraries209. Use of Synthetic Peptides for Structural and Functional Analyses of Viruses Like HIV210. Pheromone Peptides211. Fish Peptides212. Peptides and Sleep213. Peptide ChronomicsIndex