GTPases Regulating Membrane Targeting and Fusion book cover

GTPases Regulating Membrane Targeting and Fusion

Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.

Audience
Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists.

Included in series
Methods in Enzymology

Hardbound, 912 Pages

Published: December 2005

Imprint: Academic Press

ISBN: 978-0-12-182808-0

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