Prologue. Contributing Authors. Chapter 1. Introduction (S.W.J. Lamberts). Chapter 2. GHRP : Unnatural toward the natural (C.Y. Bowers). Chapter 3. Impervious peptides as GH secretagogues (R. Deghenghi). Chapter 4. GHRP Structure -activity relationship: an in vivo perspective (R. Clark). Chapter 5. Molecular analysis of the growth hormone secretagogue receptor (A.D. Howard, S.-S. Pong, K.K. McKee, O.C. Palyha, D.L. Hreniuk, C.P. Tan, R. Nargund, A.A. Patchett, L.H.T Van Der Ploeg, R.G. Smith, S.D. Feighner). Chapter 6. Intracellular GHRP signalling (C. Chen, I.J. Clarke). Chapter 7. The effects of GH-secretagogues on human pituitary cells in culture and on rat hypothalamic tissue (M. Korbonits, E.F. Adams, A.B. Grossman). Chapter 8. Hypothalamic site and mechanism of action of growth hormone secretagogues (S.L. Dickson). Chapter 9. Mechanisms of actions of growth hormone-releasing peptides and their analogues in vivo (C. Oliver, F. Dadoun, N. Briard, V. Guillaume, N. Sauze, M. Grino, A. Dutour). Chapter 10. Animal models of growth hormone deficiency as tools to study growth hormone releasing mechanisms (L.A. Frohman, R.D. Kineman). Chapter 11. Regulation of growth hormone (GH) pulsatility in humans (E.V. Dimaraki, A.L. Barkan). Chapter 12. Hormonal activities of growth hormone secretagogues (GHS) across human lifespan (E. Arvat, F. Broglio, R. Giordano, G. Muccioli, M. Maccario, F. Camanni, E. Ghigo). Chapter 13. Effectiveness of growth hormone secretagogues in the diagnosis and treatment of GH secretory deficiency (B.B. Bercu, R.F. Walker). Chapter 14. Does desensitisation to growth hormone secretagogues occur? (A. Rahim, S.M. Shalet). Chapter 15. GHRPs in human obesity (J. Svensson, J.-O. Jansson, B.-Å Bengtsson). Chapter 16. Effects of growth hormone secretagogues on in vivo substrate metabolism in humans (N. Møller, J.O. Jorgensen, J.S. Christiansen). Chapter 17. Growth hormone secretagogues. Physiological role and clinical implications (C. Dieguez, V. Popovic, D. Micic, A. Leal-Cerro, A. Penalva, R.V. Garcia-Mayor, M. Pombo, F.F. Casanueva). Chapter 18. Growth hormone secretagogues in critical illness (G.H.A. Van Den Berghe). Chapter 19. Growth hormone secretagogues in catabolic illness (R.C. Jenkins, R.J.M. Ross). Chapter 20. Treatment of children with short stature by growth hormone secretagogues (Z. Laron). Chapter 21. Therapeutic potential of GH secretagogues in adults (R.M. Nass, M.O. Thorner). Chapter 22. Growth hormone secretagogue influences feeding behaviour in experimental animals (I. Wakabayashia, H. Sugihara, T. Shibasaki). Chapter 23. Growth hormone secretagogues and sleep ( A. Steiger). Chapter 24. Hexarelin, a synthetic growth hormone secretagogue, exhibits protectant activity in experimental myocardial ischemia and reperfusion (F. Berti, G. Rossoni, V. De Gennaro Colonna). Chapter 25. Potential applications of growth hormone secretagogues (I. Shimon, S. Melmed). Index.