Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer TherapyBy
- G Sherbet, University of Newcastle upon Tyne, UK
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management.
This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.
Developmental biologists, cell biologists and cancer researchers
Hardbound, 368 Pages
Published: July 2011
1. Convergence of growth factor signalling pathways in developmental systems and pathogenesis
2. Growth factor families
3. TGF-ß family growth factors in differentiation and morphogenesis
4. Vascular endothelial growth factor5. The hepatocyte growth Factor
6. The platelet derived growth factor family
7. Nerve Growth Factors
8. Insulin-like growth factors9. Connective tissue growth factor (CTGF)10. Thrombospondins
11. Cytokines12. Growth factor and hedgehog signalling pathways meet in developmental systems13. Epidermal Growth Factors and their signalling systems14. Growth factors of the EGF family15. The fibroblast growth factor family 16. Intracellular receptor binding growth factors17. Androgens and androgen receptors (AR) in development, differentiation and neoplasia18. Vitamin D3 in cell proliferation, apoptosis and differentiation19. Retinoids in development and pattern formation20. Oestrogens and progesterone in normal physiology and neoplasia21. Glucocorticoid signalling in normal and aberrant physiology