Glycosaminoglycans in Development, Health and Disease

Edited by

  • Lijuan Zhang, Washington University School of Medicine, MO, USA

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate.

This volume discusses the role of GAGs in development, health and disease.

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Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Book information

  • Published: September 2010
  • ISBN: 978-0-12-381282-7


"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Table of Contents

  1. Mice deficient in heparan sulfate N-sulphotransferase-1
  2. Lena Kjellén and Maria Ringvall

  3. Mice deficient in heparan sulfate epimerase
  4. Jin ping Li

  5. Mice deficient in heparan sulfate 3-O-sulfotransferase-1
    Nicholas W. Shworak
  6. Mice deficient in heparan sulfate 6-O-sulfotransferase-1
  7. Koji Kimata and Hiroko Habuchi

  8. Mice deficient in dermatan sulfate Epimerase
  9. Marco Maccarana and Anders Malmström

  10. The roles of chondroitin-4-sulfotransferase-1 in development and disease
  11. Michael Klüppel

  12. Conditionally disrupted EXT1 in the embryonic mouse brain.
  13. Yu Yamaguchi

  14. Endothelial heparan sulfate in inflammation
  15. Jeffrey D. Esko and Ding Xu

  16. Endothelial heparan sulfate in angiogenesis
  17. Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang

  18. Hepatocyte heparan sulfate and lipoprotein metabolism
  19. Jeffrey D. Esko and Erin Foley

  20. Serglycin proteoglycan deletion in mouse platelet
  21. Barbara P. Schick

  22. GAGs in Amyloidosis
  23. Jin ping Li and Xiao Zhang

  24. Selectins, Heparins and Tumor Metastasis
  25. Lubor Borsig

  26. Chondroitin sulfate and Rheumatoid arthritis
  27. Lijuan Zhang

  28. Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function
  29. Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang

  30. Vascular dermatan sulfate and heparin cofactor II
  31. Douglas M. Tollefsen

  32. Diverse Functions of Glycosaminoglycans in Infectious Diseases
  33. Pyong Woo Park, Rafael Aquino, and Eui Seung Lee

  34. Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.
  35. Lijuan Zhang

  36. Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases

Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan