Glycosaminoglycans in Development, Health and Disease book cover

Glycosaminoglycans in Development, Health and Disease

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate.

This volume discusses the role of GAGs in development, health and disease.


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Hardbound, 408 Pages

Published: September 2010

Imprint: Academic Press

ISBN: 978-0-12-381282-7


    "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal


    1. Mice deficient in heparan sulfate N-sulphotransferase-1
    2. Lena Kjellén and Maria Ringvall

    3. Mice deficient in heparan sulfate epimerase
    4. Jin ping Li

    5. Mice deficient in heparan sulfate 3-O-sulfotransferase-1
      Nicholas W. Shworak
    6. Mice deficient in heparan sulfate 6-O-sulfotransferase-1
    7. Koji Kimata and Hiroko Habuchi

    8. Mice deficient in dermatan sulfate Epimerase
    9. Marco Maccarana and Anders Malmström

    10. The roles of chondroitin-4-sulfotransferase-1 in development and disease
    11. Michael Klüppel

    12. Conditionally disrupted EXT1 in the embryonic mouse brain.
    13. Yu Yamaguchi

    14. Endothelial heparan sulfate in inflammation
    15. Jeffrey D. Esko and Ding Xu

    16. Endothelial heparan sulfate in angiogenesis
    17. Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang

    18. Hepatocyte heparan sulfate and lipoprotein metabolism
    19. Jeffrey D. Esko and Erin Foley

    20. Serglycin proteoglycan deletion in mouse platelet
    21. Barbara P. Schick

    22. GAGs in Amyloidosis
    23. Jin ping Li and Xiao Zhang

    24. Selectins, Heparins and Tumor Metastasis
    25. Lubor Borsig

    26. Chondroitin sulfate and Rheumatoid arthritis
    27. Lijuan Zhang

    28. Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function
    29. Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang

    30. Vascular dermatan sulfate and heparin cofactor II
    31. Douglas M. Tollefsen

    32. Diverse Functions of Glycosaminoglycans in Infectious Diseases
    33. Pyong Woo Park, Rafael Aquino, and Eui Seung Lee

    34. Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.
    35. Lijuan Zhang

    36. Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases

    Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan


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