Glucose Metabolism in the Brain

  • Donard Dwyer

Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference.
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Basic scientists and clinical researchers in neuroscience, neurology and biochemistry.


Book information

  • Published: October 2002
  • ISBN: 978-0-12-366852-3

Table of Contents

Introduction:Energy Metabolism in the BrainThe Cerebral Glucose-Fatty Acid Cycle: Evolutionary roots, regulation, and (patho)physiological importanceExpression, Regulation and Functional Role of Glucose Transporters (GLUTs) in BrainInsulin-Like Growth Factor 1 Promotes Neuronal Glucose Utilization During Brain Development and Repair ProcessesCNS Sensing and Regulation of Peripheral Glucose LevelsGlucose Transporter Protein SyndromesGlucose, Stress, and Hippocampal Neuronal VulnerabilityGlucose/Mitochondria in Neurological Conditions Energy Utilization in the Ischemic/Reperfused BrainDiabetes Mellitus and the Central Nervous SystemDiabetes, the Brain and Behavior:Is there a biological mechanism underlying the association between diabetes and depressionSchizophrenia and DiabetesPsychoactive Drugs Affect Glucose Transport and the Regulation of Glucose Metabolism