Glioma Controversies book cover

Glioma Controversies

Basic Science, Diagnosis, and Treatment

Gliomas are a rare form of cancer in the brain and spine which originate in glial cells and are generally fatal within one year. Our understanding of gliomas is expanding rapidly and current research focusing on neuropathology, imaging, surgical options, radiation treatment, chemotherapy, and advances in basic science and experimental therapeutics is resulting in new options for clinical practitioners. These advances are not without controversy and this collection of original chapters focus on both the promising new research and the potential drawbacks of these new treatment protocols. The focus on the controversies makes this a unique and essential tutorial\reference for both the research and clinical communities involved in treating gliomas.

Audience

Clinical neurologists, neuroscience researchers, clinically practicing neurosurgeons, neurologists, neuro-oncologists, radiation oncologists, neuropathologists

Hardbound, 600 Pages

Published: April 2015

Imprint: Academic Press

ISBN: 978-0-12-407765-2

Contents

  • NEUROPATHOLOGY
    Donald Born, Section Editor

    1. Oligo’s w/o 1P/19Q deletion?
    2. Grading treated gliomas
    3. PXA grading
    4. Genetic vs. proteomic markers for neuropathologic diagnosis

    IMAGING
    James Fink, Section Editor

    1. Perfusion MRI for Glioma Assessment: Which Technique?
    2. MR Spectroscopy for Glioma Assessment: Is it Necessary?
    3. Diffusion MRI for Glioma Assessment: Is FDM Essential?
    4. PET Imaging for Glioma Assessment: Are SUVs Helpful?
    5. Advanced Imaging for Post-Radiation Treatment Assessment: Does It Really Matter?

    SURGERY
    Daniel Silbergeld, Section Editor

    1. Impact of extent of resection for gliomas
    2. Impact of Gliadel at first surgery and re-op
    3. Impact of re-op for recurrent gliomas
    4. Necessity of mapping during surgery

    RADIATION ONCOLOGY
    Jason Rockhill, Section Editor

    1. Radiation Techniques for Gliomas - including target volume
    2. Re-irradiation for recurrent Gliomas (How do you define recurrence and what technique is used.)
    3. Low-Grade Glioma - Early versus late irradiation

    CHEMOTHERAPY
    Maciej Mrugala, Section Editor

    1. Chemotherapy in the era of pseudoprogression - how to decide when to change therapy
    2. Imaging vs quality of life - what better measures successful chemotherapy
    3. The role of chemotherapy for grade III glioma
    4. When and if to introduce chemotherapy for low grade gliomas
    5. Duration of chemotherapy in treatment of gliomas - when to stop
    6. Anti-VEGF agents and their role in management of glioma patients

    BASIC SCIENCE AND EXPERIMENTAL THERAPEUTICS
    Robert Rostomily, Section Editor

    1. Stem cell theory of gliomagenesis: Is this therapeutically important?
    2. Surmounting the delivery problem: What is the answer?
    3. Imunotherapy: Decades later- will it realize its promise?
    4. “Omics”, Biomarkers and Personalized medicine: How to implement and measure success?
    5. Possible contribution of mathematical modeling

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