Ghrelin book cover

Ghrelin

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers ghrelin, and has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.

Audience

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 512 Pages

Published: September 2012

Imprint: Academic Press

ISBN: 978-0-12-381272-8

Contents

  • History of GHS and ghrelin

    1. History To The Discovery Of Ghrelin
    2. Cyril Y. Bowers

    3. Orphan Gpcrs And Methods For Identifying Their Ligands
    4. Morikatsu Yoshida, Mikiya Miyazato, and Kenji Kangawa

    5. Purification Of Rat And Human Ghrelins
    6. Masayasu Kojima, Hiroshi Hosoda and Kenji Kangawa

    7. Variety of Acyl Modifications in Mammalian Ghrelins
    8. Takanori Ida

    9. Determination Of Non-Mammalian Ghrelin
    10. Hiroyuki Kaiya, Hiroshi Hosoda, Kenji Kangawa, Mikiya Miyazato

      Molecular forms of ghrelin and Measuring of the concentrations

    11. Morphological Analysis Of Ghrelin Neurons In The Hypothalamus
    12. Haruaki Kageyama, Fumiko Takenoya and Seiji Shioda

    13. High-Performance Liquid Chromatography Analysis Of Hypothalamic Ghrelin
    14. Takahiro Sato and Masayasu Kojima

    15. Standard Sample Collections For Blood Ghrelin Measurements
    16. Hiroshi Hosoda and Kenji Kangawa

      Enzymes for processing of ghrelin

    17. From Ghrelin to Ghrelin’s O Acyl Transferase
    18. Jesus A. Gutierrez, Jill A. Willency, Michael D. Knierman, Tamer Coskun, Patricia J. Solenberg, Doug R. Perkins, Richard E. Higgs, and John E. Hale.

    19. Enzymatic Characterization Of Goat, Ghrelin O-Acyltransferase
    20. Hideko Ohgusu, Tomoko Takahashi and Masayasu Kojima

    21. The Study Of Ghrelin Deacylation Enzymes
    22. Motoyasu Satou and Hiroyuki Sugimoto

      Synthesis of ghrelin agonists and antagonists

    23. SynthesisOf Ghrelin:Chemical Synthesis And Semi-Synthesis For Large-Scale Preparation Of Modified Peptides
    24. Tomohiro Makino, Masaru Matsumoto and Yoshiharu Minamitake

    25. Ghrelin O-Acyltransferase Assays And Inhibition
    26. Martin S. Taylor, Yousang Hwang, Po-Yuan Hsiao, Jef D. Boeke, Philip A. Cole

      Action of ghrelin

    27. Model-Based Evaluation Of Growth Hormone Secretion
    28. Johannes D. Veldhuis, Daniel M. Keenan

    29. Ghrelin In The Control Of Energy, Lipid And Glucose Metabolism
    30. Kristy M. Heppner, Timo D. Müller, Jenny Tong, and Matthias H. Tschöp

    31. Ghrelin And The Vagus Nerve
    32. Yukari Date

    33. Measurement of amp-activated protein kinase (ampk) activity and expression In response to ghrelin
    34. Chung Thong Lim, Francesca Lolli, Julia D Thomas, Blerina Kola, Márta Korbonits

    35. Ghrelin And Gastrointestinal Movement
    36. Naoki Fujitsuka, Akihiro Asakawa, Haruka Amitani, Mineko Fujimiya, Akio Inui

    37. Ghrelin Acylation By Ingestion Of Medium-Chain Fatty Acids
    38. Yoshihiro Nishi, Hiroharu Mifune, and Mayasu Kojima

    39. Islet ß-cell Ghrelin Signaling For Inhibition Of Insulin Secretion
    40. Katsuya Dezaki & Toshihiko Yada

    41. Rikkunshito As A Ghrelin Enhancer
    42. Hiroshi Takeda, Shuichi Muto, Koji Nakagawa, Shunsuke Ohnishi, Chiharu Sadakane, Yayoi Saegusa, Miwa Nahata, Tomohisa Hattori and Masahiro Asaka

      Tg and KO mice of ghrelin

    43. Thermogenic Characterization Of Ghrelin Receptor Null Mice
    44. Ligen Lin and Yuxiang Sun

    45. Transgenic Mice Over-Expressing Ghrelin Or Ghrelin Analog
    46. Hiroyuki Ariyasu, Go Yamada, Hiroshi Iwakura, Takashi Akamizu, Kenji Kangawa and Kazuwa Nakao

      Clinical application of ghrelin

    47. Therapeutic Potential Of Ghrelin In Restricting-Type Anorexia Nervosa
    48. Mari Hotta, Rina Ohwada, Takashi Akamizu, Tamotsu Shibasaki, Kenji Kangawa

    49. Clinical Application Of Ghrelin For Chronic Respiratory Diseases
    50. Nobuhiro Matsumoto, Masamitsu Nakazato

    51. Clinical Trial Of Ghrelin Synthesis Administration For Upper Gi Surgery

    Shuji Takiguchi, Yuichiro Hiura, Yasuhiro Miyazaki, Akihiro Takata, and Yuichoro Doki

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