Genetic Dissection of Complex Traits

Edited by

  • D.C. Rao, Washington University School of Medicine, St. Louis, MO, USA
  • C. Charles Gu

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
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Geneticists, molecular biologists, neurobiologists


Book information

  • Published: March 2008
  • ISBN: 978-0-12-373883-7

Table of Contents

I OVERVIEW AND FUNDAMENTALS1 An Overview of Genetic Dissection of Complex Traits D. C. Rao 2 Familial Resemblance and Heritability Treva K. Rice 3 Linkage and Association: Basic Concepts Ingrid B. Borecki and Micheal A. Province 4 Definition of Phenotype Mary K. Wojczynski and Hemant K. Tiwari 5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide ScansKaren Maresso and Ulrich Broeckel 6 Genotyping Errors and their Impact on Genetic Analysis Michael B. Miller, Karen Schwander, and D.C. Rao II LINKAGE AND ASSOCIATION ANALYSIS7 Model-Based Methods for Linkage Analysis John P. Rice, Nancy L. Saccone and Jonathan Corbett 8 Contemporary Model-Free Methods for Linkage Analysis Laura Almasy and John Blangero 9 DNA Sequence-Based Phenotypic Association Analysis Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo 10 Family-Based Methods for Linkage and Association Analysis Nan M. Laird and Christoph Lange11 Searching for Additional Disease Loci in a Genomic RegionGlenys Thomson and Lisa F. Barcellos12 Methods for Handling Multiple Testing Treva Rice, Nicholas J. Schork and D.C. RaoIII SPECIAL TOPICS13 Meta-analysis Methods Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis14 Haplotype Association AnalysisNianjun Liu, Kui Zhang, and Hongyu Zhao 15 Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies C. Charles Gu, Kai Yu, and D.C. Rao16 Associations among Multiple Markers and Complex Disease: Models, Algorithms, and ApplicationsThemistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan and Richard A. Olshen 17 Optimum Study Designs for Genome-Wide Association StudiesPeter Kraft and David G. Cox18 Ethical, Legal, and Social Implications of Biobanks for Genetics ResearchSusanne B. Haga and Laura M. BeskowIV PROMISING TOPICS 19 Admixture Mapping and the Role of Population Structure for Localizing Disease Genes Xiaofeng Zhu, Hua Tang, and Neil Risch20 Integrating Global Gene Expression Analysis and GeneticsCharles R. Farber and Aldons J. Lusis 21 A Systems Biology Approach to Drug DiscoveryJun Zhu, Bin Zhang, and Eric E. Schadt 22 The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges Na Li 23 Comparative Genomics for Detecting Human Disease GenesCarol Moreno, Jozef Lazar, Howard J. Jacob and Anne E. KwitekV OUTSTANDING CHALLENGES24 From Genetics to Mechanism of Disease LiabilityAndreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel25 Into the Post-HapMap EraNewton E. Morton