Genetic Dissection of Complex Traits

Edited by

  • D. Rao, Washington University Medical School, Division of Biostatistics, St. Louis, Missouri, U.S.A.

Genetic Dissection of Complex Traits will present the full range of methodologies that are essential for understanding the basis of human genetic disorders, the origin of such diseases, and theories on how to determine one's genetic predisposition to certain genetic diseases.
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Graduate students, scientists, and clinicians working in genetic research.


Book information

  • Published: October 2000
  • ISBN: 978-0-12-017642-7


"Genetic Dissection of Complex Traits provides an extensive overview of contemporary methods for statistical gene mapping."
—Alexandre A. Todorov for AMERICAN JOURNAL OF HUMAN GENETICS (July 2002)

Table of Contents

Contributors.Preface.Acknowledgments.NEWTON MORTON'S CONTRIBUTIONSNewton Morton: The Wisconsin Years.Newton Morton's Influence on Genetics: The Morton Number.OVERVIEW AND PRELIMINARIESGenetic Dissection of Complex Traits: An Overview.Familial Resemblance and Heritability.Linkage and Association: Basic Concepts.PHENOTYPES AND GENOTYPESDefinition of the Phenotype.Genotyping for Human Whole-Genome Scans: Past, Present, and Future.MODEL-BASED METHODS FOR LINKAGE ANALYSISThe Lod Score Method.Extension of the Lod Score: The Mod Score.Major Strengths and Weaknesses of the Lod Score Method.MODEL-FREE METHODS FOR LINKAGE AND ASSOCIATION ANALYSISOverview of Model-free Methods for Linkage Analysis.Variance Component Methods for Detecting Complex Trait Loci.Linkage and Association with Structural Relationships.The Future of Genetic Case-Control Studies.Cost of Linkage versus Association Methods.Genotype-Environment Interaction in Transmission Disequilibrium Tests.Major Strengths and Weaknesses of Model-free Methods.MORE RECENT METHODSMeta-analysis for Model-free Methods.Classification Methods for Confronting Heterogeneity.Applications of Neural Networks for Gene Finding.Genome Partitioning and Whole-Genome Analysis.Deciphering the Genetic Architecture of a Multivariate Phenotype.OPTIMUM STRATEGIESOn the Resolution and Feasibility of Genome Scanning Approaches.One-Stage versus Two-Stage Strategies for Genome Scans.MULTIPLE COMPARISONS AND SIGNIFICANCE LEVELSSignificance Levels in Genome Scans.False Positives and False Negatives in Genome Scans.Sequential Methods of Analysis for Genome Scans.CHALLENGES FOR THE NEW MILLENNIUMFrom Genetics to Mechanism of Disease Liability.Complex Inheritance: The 21st Century.Appendix: Research Contributions of Newton E. Morton.Index.