Gene Transfer Vectors for Clinical Application
This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design.
Included in series
Methods in Enzymology
Methods in Enzymology
Hardbound, 440 Pages
Published: March 2012
Imprint: Academic Press
ISBN: 978-0-12-386509-0
Contents
- Preface: The successful clinical use of viral vectors for human gene therapy. Theodore Friedmann
- General principles of retrovirus vector design Tammy Chang And Jiing-Kuan Yee
- Strategies for retrovirus-based correction of severe, combined immunodeficiency (SCID) Alain Fischer, Salima Hacein-Bey and Marina Cavazzana-Calvo
- Retrovirus and lentivirus vector design and methods of cell conditioning Samantha Cooray, Stephen J Howe and Adrian J Thrasher
- Analysis of the clonal repertoire of gene corrected cells in gene therapy Anna Paruzynski, Hanno Glimm, Manfred Schmidt and Christof von Kalle
- Developing novel lentiviral vectors into clinical products Anna Leath and Kenneth Cornetta
- Lentivirus vectors in beta-thalassemia Emmanuel Payen, Charlotte Colomb, Olivier Negre, Yves Beuzard, Kathleen Hehir and Philippe Leboulch
- Gene Therapy for Chronic Granulomatous Disease Elizabeth M. Kang, and Harry L. Malech
- Alternative splicing caused by lentiviral integration in the human genome Arianna Moiani and Fulvio Mavilio
- Genotoxicity assay for gene therapy vectors in tumor prone Cdkn2a -/- mice Eugenio Montini and Daniela Cesana
- Lentiviral Hematopoietic Cell Gene Therapy for X-linked Adrenoleukodystrophy Nathalie Cartier, Salima Hacein-Bey-Abina , Cynthia C. Bartholomae, Pierre Bougnères , Manfred Schmidt, Christof Von Kalle, Alain Fischer, Marina Cavazzana-Calvo and Patrick Aubourg
- Retroviral replicating vectors in cancer Christopher R. Logg , Joan M. Robbins , Douglas J. Jolly , Harry E. Gruber , and Noriyuki Kasahara
- Adeno-associated virus vectorology, manufacturing and clinical applications Joshua C. Grieger and R. Jude Samulski
- Gene Delivery To The Retina: From Mouse To Man Jean Bennett, Daniel C. Chung, and Albert Maguire
- Generation of hairpin-based RNAi vectors for biological and therapeutic application Ryan L. Boudreau and Beverly L. Davidson
- Recombinant adeno-associated viral vector reference standards Philippe Moullier and Richard O. Snyder
- NIH oversight of human gene transfer research involving retroviral, lentiviral and adeno-associated virus vectors and the role of the NIH recombinant DNA advisory committee draft Marina OReilly, Allan Shipp, Eugene Rosenthal, Robert Jambou, Tom Shih, Maureen Montgomery, Linda Gargiulo, Amy Patterson and Jacqueline Corrigan-Curay
- Regulatory structures for gene therapy medicinal products in the European Union
