Gene Expression in the Central Nervous System book cover

Gene Expression in the Central Nervous System

Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.

Included in series
Progress in Brain Research

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Published: August 1995

Imprint: Elsevier

ISBN: 978-0-444-81852-2

Contents

  • List of contributors. Preface. Section I - Techniques in Analysis of Gene Expression. 1. The gene knockout technology for the analysis of learning and memory, and neural development. 2. Molecular biology of transmissible spongiform encephalopathies. 3. Molecular genetic analysis of myelin deficiency and cerebellar ataxia. 4. Gene expression of serotonergic neurons in the central nervous system: molecular and developmental analysis. Section II - Signal Transduction and Gene Expression. 5. The involvement of PKC and multifunctional CaM kinase II of post-synaptic neuron in induction and maintenance of long-term potentiation (T.P. Feng). 6. Neuronal calcium channels encoded by the &agr;1A subunit and their contribution to excitatory synaptic transmission in the CNS. 7. Synaptic vesicle proteins and regulated exocytosis. 8. The molecular organization of voltage-dependent K+ channels in vivo. 9. Decoding Ca2+ signals to the nucleus by multifunctional CaM kinase. 10. Kainate-induced changes in gene expression in the rat hippocampus. 11. Mechanisms of neuronal plasticity as analyzed at the single cell level. Section III - Development, Differentiation, and Aging. 12. Plasticity and commitment in the developing cerebral cortex. 13. Growth factors in the CNS and their effects on oligodendroglia. 14. Social control of cell size: males and females are different. 15. The differentiation and function of the touch receptor neurons of Caenorhabditis elegans. 16. Functions of the L2/HNK-1 carbohydrate in the nervous system. 17. Neurotrophic factors and their receptors. 18. Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. 19. Plasticity of developing neuromuscular synapses. 20. A RT-PCR study of gene expression in a mechanical injury model. 21. Stimulation of phospholipase A2 expression in rat cultured astrocytes by LPS, TNF&agr; and IL-1&bgr; 22. Correlation between proto-oncogene, fibroblast growth factor and adaptive response in brain infarct. 23. Gene expression in astrocytes during and after ischemia. 24. Gene expression of neurotropic retrovirus in the CNS. 25. Cholecystokinin octapeptide (CCK-8): a negative feedback control mechanism for opioid analgesia. 26. The transport of neurotransmitters into synaptic vesicles. 27. Preliminary molecular neurobiology study on the pathogenesis of primary epilepsy. 28. Expression of immune-related molecules in a murine genetic demyelinating disease. 29. Expression of myelin proteolipid protein in oligodendrocytes and transfected cells. 30. Glial fibrillary acidic protein mRNA and the development of gliosis in mice with chronic relapsing experimental allergic encephalomyelitis. 31. Structure and function of peripheral nerve myelin proteins. 32. The molecular basis of the neuropathies of mouse and human. 33. Expression of the neurofibromatosis type 1 (NF1) gene during mouse embryonic development. Subject index.

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