Gas Chromatography and Mass Spectrometry: A Practical Guide book cover

Gas Chromatography and Mass Spectrometry: A Practical Guide

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry.

The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated.


Immediate value to the novice as well as the experienced GC/MS user who may not have the breadth of knowledge covered in this book.

Paperback, 632 Pages

Published: March 2011

Imprint: Academic Press

ISBN: 978-0-12-373628-4


  • "The authors have kept this book relevant and timely and have achieved their goal of providing useful information for practitioners. They understand what those who actually use GC/MS need, and continue to add appendixes of numerical information (increased from 12 to 17 in this revision)…The entire book has been updated and improved where needed; for example, chapter 6, covering the challenging topic of quantitation, has been "completely reworked." Sparkman and his collaborators continue to write high-quality books that are extremely useful, precise, and interesting to both novices and experienced scientists. Summing Up: Highly recommended. Upper-division undergraduates through professionals/practicioners."--CHOICE


  • Preface
    1 Introduction and History
    2 Gas Chromatography
    3 The GC/MS Interface
    4 Mass Spectrometry Instrumentation
    5 Mass Spectral Data Interpretation
    6 Quantitation with GC/MS
    7 Acids
    8 Alcohols
    9 Aldehydes
    10 Amides
    11 Amines
    12 Amino Acids
    13 Common Contaminants
    14 Drugs and Their Metabolites
    15 Esters
    16 Ethers
    17 Fluorinated Compounds
    18 Gases
    19 Glycols
    20 Halogenated Compounds (Other Than Fluorinated Compounds)
    21 Hydrocarbons
    22 Isocyanates
    23 Ketones
    24 Nitriles
    25 Nitroaromatics
    26 Nitrogen-Containing Heterocyclic Compounds
    27 Nucleosides (TMS Derivatives)
    28 Pesticides
    29 Phenols
    30 Phosphorus Compounds
    31 Plasticizers and Other Polymer Additives (Including Phthalates)
    32 Prostaglandins (MO-TMS Derivatives)
    33 Solvents and Their Impurities
    34 Steroids
    35 Sugars (Monosaccharides)
    36 Sulfur Compounds
    Section 3 APPENDICES
    Appendix A Definitions of Terms Related to Gas Chromatography
    Appendix B Definitions of Terms Related to Mass Spectrometry
    Appendix C Atomic Masses and Isotope Abundances and Other Information for the Determination of an Elemental Composition from Isotope Peak Intensity Ratios
    Appendix D X+1 and X+2 Values for Ions Containing Atoms of C and H Based on Isotope Contributions
    Appendix E Isotope Peak Patterns for Ions Containing Atoms of Cl and/or Br
    Appendix F Steps to Follow in the Determination of an Elemental Composition Based on Isotope Peak Intensity Ratios
    Appendix G Derivatization in GC/MS
    Appendix H Points of Comparison of LC/MS vs GC/MS
    Appendix I List of Available EI Mass Spectral Databases
    Appendix J Information Required for Reporting a GC/MS Analysis
    Appendix K Third-Party Software for Use with GC/MS
    Appendix L GC Installation and Maintenance
    Appendix M Troubleshooting Common GC Problems
    Appendix N Maintenance, Operating Tips, and Troubleshooting for Mass Spectrometers
    Appendix O Mixtures for Determining Mass Spectral Resolution
    Appendix P Cross-Index Chart for GC Stationary Phases
    Appendix Q Ions for Determining Unknown Structures


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