GABAb Receptor Pharmacology: A Tribute to Norman Bowery

  • Thomas Blackburn

This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

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The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.


Book information

  • Published: August 2010
  • ISBN: 978-0-12-378647-0

Table of Contents

  1. Historical Perspective and Emergence of the GABAB Receptor
  2. Norman Bowery

  3. Chemistry of GABAB Receptor Ligands
  4. Wolfgang Froestl

  5. Heterodimerization of the GABAB Receptor - Implications for GPCR Signaling and Drug Discovery
  6. Fiona H. Marshall and Steven M. Foord

  7. Mechanisms of GABAB Receptor Exocytosis, Endocytosis and Degradation
  8. Deitmar Benke

  9. Functional Modulation of GABAB Receptors by Protein Kinases and Receptor Trafficking
  10. Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss

  11. GABAB Receptor Coupling to G Proteins and Ion Channels
  12. Claire Padgett and Paul A. Slesinger

  13. GABAB Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons
  14. M. Kano and Toshihide Tabata

  15. GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?
  16. Guillermo Gonzalez-Burgos

  17. The Role of GABAB Receptors in Cortical Network Activity
  18. Michael M. Kohl and Ole Paulsen

  19. GABAB Receptors: Physiology Functions and Mechanisms of Diversity
  20. Andree Pinard, Riad Seddik, and Bernhard Bettler

  21. Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure
  22. De-Pei Li and Hui-Lin Pan

  23. GABAB Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease
  24. Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens

  25. GABAB Receptors in Reward Processes
  26. Styliani Vlachou and Athina Markou

  27. GABAB Receptors in Addiction and Its Treatment
  28. David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke

  29. GABAB - GIRK2 Mediated Signaling in Down Syndrome
  30. Nathan Cramer, Tyler Best, and Zygmunt Galdzicki

  31. GABAB Receptors and Depression: Current Status
  32. John F. Cryan and David A. Slattery

  33. GABAB Receptors in Drosophila

Hari Manev and Svetlana Dzitoyeva