GABAb Receptor Pharmacology: A Tribute to Norman Bowery

1. Historical Perspective and Emergence of the GABA B Receptor

Norman Bowery

2. Chemistry of GABA B Receptor Ligands

Wolfgang Froestl

3. Heterodimerization of the GABA B Receptor - Implications for GPCR Signaling and Drug Discovery

Fiona H. Marshall and Steven M. Foord

4. Mechanisms of GABA B Receptor Exocytosis, Endocytosis and Degradation

Deitmar Benke

5. Functional Modulation of GABA B Receptors by Protein Kinases and Receptor Trafficking

Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss

6. GABA B Receptor Coupling to G Proteins and Ion Channels

Claire Padgett and Paul A. Slesinger

7. GABA B Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons

M. Kano and Toshihide Tabata

8. GABA Transporter GAT1: A Crucial Determinant of GABA B Receptor Activation in Cortical Circuits?

Guillermo Gonzalez-Burgos

9. The Role of GABA B Receptors in Cortical Network Activity

Michael M. Kohl and Ole Paulsen

10. GABA B Receptors: Physiology Functions and Mechanisms of Diversity

Andree Pinard, Riad Seddik, and Bernhard Bettler

11. Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure

De-Pei Li and Hui-Lin Pan

12. GABA B Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease

Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens

13. GABA B Receptors in Reward Processes

Styliani Vlachou and Athina Markou

14. GABA B Receptors in Addiction and Its Treatment

David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke

15. GABA B - GIRK2 Mediated Signaling in Down Syndrome

Nathan Cramer, Tyler Best, and Zygmunt Galdzicki

16. GABA B Receptors and Depression: Current Status

John F. Cryan and David A. Slattery

17. GABA B Receptors in Drosophila

Hari Manev and Svetlana Dzitoyeva