Edited by

  • S. J. Enna, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, USA
  • J. August, John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.
  • Ferid Murad, University of Texas Medical School, Houston, U.S.A.

A great deal of progress has been made in defining GABA (gamma-aminobutyric acid) transmission in the brain. Volume 54 of the Advances in Pharmacology series has also provided new insights into fundamental features of neurotransmission in general, such as the importance of allosterism and coincident signaling in regulating receptor function and overall cellular activity. These studies have led to the design and development of new drugs and potential therapeutic agents. Given the successes achieved over the first 50 years of GABA research, it is certain the 6th decade will yield its share of surprising discoveries and new insights. Published in this volume are articles providing thoughts and perspectives on this topic, some with the benefit of hindsight, others in the context of recent findings, but all with a hint, or prediction, of what the future holds as the secrets of GABA neurotransmission continue to unfold.Advances in Pharmacology is available online on ScienceDirect — full-text online of volumes 48 onwards.
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Academics and researchers in neuroscience, genetics, pharmacology, biology, neurology, and physiology.


Book information

  • Published: July 2006
  • ISBN: 978-0-12-032957-1


PRAISE FOR THE SERIES "Recommended not only to pharmacologists but also to all those in related disciplines." -NATURE

Table of Contents

1. The regulation of GABA cell viability in psychotic disorders2. Involvement of GABA-B receptors in the thalamic processing of nociceptive information3. GABA-B receptor subunit expression: Pharmacological and physiological implications4. Epigenetic modulation of GABA-A receptors in psychiatric disorders5. From gene to behavior and back again: New perspectives on the GABA-A receptor subunit selectivity6. Modulation of inotropic GABA receptors by natural products7. A role for GABA in alcohol dependence8. GABA-A agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic9. GABA-A receptor epilepsy mutations10. Role of Na/K ratio in GABA transport11. Structure-activity studies and functional pharmacology of GABA transporters12. Structure, pharmacology, and function of GABA-A receptor subtypes13. Pharmacological characteristics of GABA uptake inhibitors