Gaba in Autism and Related Disorders

Edited by

  • Dirk Dhossche, Department of Psychiatry & Human Behavior, University of Mississippi Medical Center, Jackson, USA

Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.
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Neurologists, neurosurgeons, neuroradiologists and other neuroscientists who are dedicated to the advancement of techniques used to evaluate the neurobiology of autism.


Book information

  • Published: December 2005
  • ISBN: 978-0-12-366872-1

Table of Contents

Foreword by Eugene RobertsAutism: neuropathology, alterations of the GABAergic system, and animal modelsThe role of GABA in the early neuronal developmentGABAergic signaling in the developing cerebellumInsights into GABA functions in the developing cerebellumRole of GABA in the Mechanism of the Onset of Puberty in Non-Human PrimatesRett Syndrome: A Rosetta Stone for Understanding the Molecular Pathogenesis of AutismGABAergic Cerebellar System in Autism: A Neuropathological and Developmental PerspectiveReelin Glycoprotein in Autism and SchizophreniaIs there a connection between autism, Prader-Willi syndrome, catatonia and GABA?The role of GABA in prenatal alcohol exposureEffects of secretin on extracellular GABA and other amino acid concentractions in the rat hippocampusPredicted therapeutic role of secretin and oxytocin in augism: Implications for treatment of mental illnessImmunological Findings in AutismCorrelates of psychomotor symptoms in autismGabrb3 Gene Deficient Mice: A Potential Model of Autism Spectrum DisorderThe Reeler Mouse: Anatomy of a MutantGABA-A receptor mutations in epilepsy and other disordersShared chromosomal susceptibility regions between autism and other mental disorders