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G Protein Coupled Receptors

Trafficking and Oligomerization

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs.

Hardbound, 480 Pages

Published: February 2013

Imprint: Academic Press

ISBN: 978-0-12-391862-8

Contents

    • GPCR Trafficking

      1. Therapeutic Rescue of Misfolded/Mistrafficked Mutants: Automation-Friendly High Throughput Assays for Identification of Pharmacoperone Drugs of GPCRs

        2. David C. Smithson, Jo Ann Janovick, P. Michael Conn

      2. Trafficking of the Follitropin Receptor

        3. Alfredo Ulloa-Aguirre, James A. Dias, George Bousfield, Ilpo Huhtaniemi, and Eric Reiter

      3. Single Molecule Imaging Technique to Study the Dynamic Regulation of GPCR Function at the Plasma Membrane

        4. B.E. Snaar-Jagalska, A. Cambi, T. Schmidt and S. de Keijzer

      4. GPCR Oligomerization and Receptor Trafficking

        5. Richard J. Ward, Tian-Rui Xu and Graeme Milligan

      5. b-Arrestins and G Protein-Coupled Receptor Trafficking

        6. Dong Soo Kang, Xufan Tian, and Jeffrey L. Benovic

      6. Tracking Cell Surface Mobility of GPCRs Using a-Bungarotoxin Linked Fluorophores

        7. Saad Hannan, Megan E Wilkins, P Thomas and Trevor G Smart

      7. Regulatory Mechanism of G Protein-Coupled Receptor Trafficking to the Plasma Membrane: A Role for mRNA Localization

        8. Kusumam Joseph, Eleanor K. Spicer and Baby G. Tholanikunnel

      8. Dissecting Trafficking and Signaling of Atypical Chemokine Receptors

        9. Elena Borroni, Cinzia Cancellieri, Massimo Locati, Raffaella Bonecchi


        Trafficking Motifs

      9. Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs

        10. Carl M. Hurt, Vincent K. Ho, and Timothy Angelotti

      10. Identification of Endoplasmic Reticulum Export Motifs for G Protein-Coupled Receptors

        11. Guangyu Wu

      11. Amino Acid Residues of G-Protein Coupled Receptors Critical for Endoplasmic Reticulum Export and Trafficking

        12. Motonao Nakamura, Daisuke Yasuda, Nobuaki Hirota, Teruyasu Yamamoto, Satoshi Yamaguchi, Takao Shimizu and Teruyuki Nagamune

        GPCR Oligomerization

      12. G Protein-Coupled Heteromers Regulation in Disease

        13. Ivone Gomes, Achla Gupta and Lakshmi A. Devi

      13. Hetero-Oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction

        14. Tokiko Suzuki, Kazunori Namba, Natsumi Mizuno and Hiroyasu Nakata

      14. Bimolecular Fluorescence Complementation Analysis of G Protein-Coupled Receptor Dimerization in Living Cells

        15. Karin F.K. Ejendal, Jason M. Conley, Chang-Deng Hu, and Val J. Watts

      15. G-Protein Coupled Receptor Heterodimerization in the Brain

        16. Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Pere Garriga, Francisco Ciruela, Manuel Narvaez, Alexander O. Tarakanov, Miklós Palkovits, Luigi F. Agnati and Kjell Fuxe

      16. Experimental Strategies for Studying G Protein-Coupled Receptor Homo- and Heteromerization with Radioligand Binding and Signal Transduction Methods

        17. Roberto Maggio, Cristina Rocchi, and Marco Scarselli

      17. Analysis of GPCRs Dimerization Using Acceptor Photobleaching Resonance Energy Transfer Techniques

        18. Marta Busnelli, Mario Mauri, Marco Parenti and Bice Chini

      18. Techniques for the Discovery of GPCR-Associated Protein Complexes

        19. Avais Daulat , Pascal Maurice and Ralf Jockers

      19. Expression, Purification and Analysis of GProtein-Coupled Receptor Kinases

        20. Rachel Sterne-Marr, Alison I. Baillargeon, Kevin R. Michalski, and John J. G. Tesmer

      20. Modern Methods to Investigate the Oligomerization of Glycoprotein Hormone Receptors (TSHR,LHR, FSHR)

      Marco Bonomi and Luca Persani

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