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G Protein Coupled Receptors

Structure

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

Hardbound, 440 Pages

Published: February 2013

Imprint: Academic Press

ISBN: 978-0-12-391861-1

Contents

      1. Expression of GPCRs in Pichia pastoris for structural studies

        Christoph Krettler, Christoph Reinhart and Carville G. Bevans

      2. Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding

        3. Ravinder Abrol, Soo-Kyung Kim, Jenelle K. Bray, Bartosz Trzaskowski, and William A. Goddard III

      3. Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach

        4. Jean-Michel Bécu, Julien Pelé, Patrice Rodien, Hervé Abdi and Marie Chabbert

      4. Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability

        5. Karola M. Schlinkmann and Andreas Plückthun

      5. The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors

        6. Gianluigi Caltabiano, Angel González, Arnau Cordomí, Mercedes Campillo, and Leonardo Pardo

      6. Structure of ß-Adrenergic Receptors

        7. Florian Brueckner, Chayne L. Piscitelli, Ching-Ju Tsai, Jörg Standfuss, Xavier Deupi and Gebhard F.X. Schertler

      7. Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors

        8. Xiang-Qun Xie and Ananda Chowdhury

      8. Crystallogenesis of Adenosine A 2A Receptor - T4 Lysozyme Fusion Protein: A Practical Route for the Structure

        9. Yashwanth Ashok, Rahul T. Nanekar & Veli-Pekka Jaakola

      9. Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors

        10. Kenneth A. Jacobson, Stefano Costanzi, and Francesca Deflorian

      10. Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs

        11. Alain Couvineau, Yossan-Var Tan, Emilie Ceraudo and Marc Laburthe

      11. Expression of Mammalian G Protein-Coupled Receptors in Caenorhabditis Elegans

        12. Beata Jastrzebska, David Salom, Hui Jin, Pengxiu Cao, Wenyu Sun, Krzysztof Palczewski, and Zhaoyang Feng

      12. Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors

        13. Angela Seebahn, Heinrich Sticht and Ralf Enz

      13. Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling

        14. Thomas Huber, Saranga Naganathan, He Tian, Shixin Ye, and Thomas P. Sakmar

      14. Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers

        15. Amy Grunbeck, Thomas Huber, Thomas P. Sakmar

      15. Alternative mRNA Splicing of G Protein-Coulped Receptors

        16. Danijela Markovic

      16. Functional Residues of the CB1 Cannabinoid Receptor

      Joong-Youn Shim and Lea Padgett

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