G Protein Coupled Receptors book cover

G Protein Coupled Receptors

Structure

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

Audience
Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 440 Pages

Published: February 2013

Imprint: Academic Press

ISBN: 978-0-12-391861-1

Contents

      1. Expression of GPCRs in Pichia pastoris for structural studies

        Christoph Krettler, Christoph Reinhart and Carville G. Bevans

      2. Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding
      3. Ravinder Abrol, Soo-Kyung Kim, Jenelle K. Bray, Bartosz Trzaskowski, and William A. Goddard III

      4. Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach
      5. Jean-Michel Bécu, Julien Pelé, Patrice Rodien, Hervé Abdi and Marie Chabbert

      6. Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability
      7. Karola M. Schlinkmann and Andreas Plückthun

      8. The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors
      9. Gianluigi Caltabiano, Angel González, Arnau Cordomí, Mercedes Campillo, and Leonardo Pardo

      10. Structure of β-Adrenergic Receptors
      11. Florian Brueckner, Chayne L. Piscitelli, Ching-Ju Tsai, Jörg Standfuss, Xavier Deupi and Gebhard F.X. Schertler

      12. Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors
      13. Xiang-Qun Xie and Ananda Chowdhury

      14. Crystallogenesis of Adenosine A2A Receptor – T4 Lysozyme Fusion Protein: A Practical Route for the Structure
      15. Yashwanth Ashok, Rahul T. Nanekar & Veli-Pekka Jaakola

      16. Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors
      17. Kenneth A. Jacobson, Stefano Costanzi, and Francesca Deflorian

      18. Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs
      19. Alain Couvineau, Yossan-Var Tan, Emilie Ceraudo and Marc Laburthe

      20. Expression of Mammalian G Protein-Coupled Receptors in Caenorhabditis Elegans
      21. Beata Jastrzebska, David Salom, Hui Jin, Pengxiu Cao, Wenyu Sun, Krzysztof Palczewski, and Zhaoyang Feng

      22. Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors
      23. Angela Seebahn, Heinrich Sticht and Ralf Enz

      24. Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling
      25. Thomas Huber, Saranga Naganathan, He Tian, Shixin Ye, and Thomas P. Sakmar

      26. Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers
      27. Amy Grunbeck, Thomas Huber, Thomas P. Sakmar

      28. Alternative mRNA Splicing of G Protein-Coulped Receptors
      29. Danijela Markovic

      30. Functional Residues of the CB1 Cannabinoid Receptor

      Joong-Youn Shim and Lea Padgett

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