G Protein-Coupled Receptors in Health and Disease, Part A book cover

G Protein-Coupled Receptors in Health and Disease, Part A

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Audience

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Hardbound, 224 Pages

Published: August 2009

Imprint: Academic Press

ISBN: 978-0-12-374757-0

Reviews

  • PRAISE FOR THE SERIES
    "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."-British Medical Journal


Contents

  • 1. Rhodopsin-Mediated Retinitis Pigmentosa

    Katherine M. Malanson and Janis Lem

    2. Human Diseases Associated with GPR54 Mutations

    Milena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico

    3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) Mutations

    Marco Martari and Roberto Salvatori

    4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin Cancer

    Kimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm

    5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome

    Lucila L K Elias and Adrian J L Clark

    6. Mutations in melanocortin-4 receptor and human obesity

    Ya-Xiong Tao

     

     

     

     

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