Functional Neural Transplantation II. Novel Cell Therapies for CNS DisordersEdited by
- S.B. Dunnett, School of Biosciences, Cardiff University, Biomedical Sciences Building, Museum Avenue, Cardiff CF1 3VS, Wales, UK
- A. Bjorklund, Department of Physiological Sciences, Wallenberg Neuroscience Center, Biomedical Center A11, S-22184 Lund, Sweden
The first edition of Functional Neural Transplantation, appearing in 1994, was commissioned to provide a systematic overview of the main areas of active research into the use of neural transplantation for functional repair at that time. There have though been major developments in the field over the last decade. First, whereas many of the model systems are the same, the sophistication of the research has developed dramatically. Secondly, there has been a major change in focus related to the nature of the optimal reparative process, moving away from a primary goal involving repair by replacement of lost cells, to strategies based on halting or reversing the disease process itself. Thirdly, the last decade has (not surprisingly) seen an expansion in the breadth of clinical applications for transplantation not only of primary embryonic neural tissues but also the initial applications of cells and cell lines.
In order to address these recent developments as we enter the 21st century, 10 years after conception and 6 years after the publication of Functional Neural Transplantation, the Editors have now sought to co-ordinate and edit an updated version, Functional Neural Transplantation II.
Functional Neural Transplantation II is not just a revised edition of the previous volume, but an entirely new and complementary second volume to update the field to 'state of the art' for the new millennium. For many major topic areas (such as functional repair in neurodegenerative disorders of the basal ganglia) there has been a continual flow of significant advances. Although these topics are covered in both volumes, the Editors have sought to avoid duplication by requiring that the present coverage emphasises the major developments over the last decade while relying on the first volume for the background overviews. Other topics though are entirely new in the present volume, such as novel applications of neural transplantation to other major clinical relevance such as retinal repair or alleviation of pain. A key departure of the present volume is the addition of several early chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, precursor/stem cells and xenotransplantation.
Progress in Brain Research
- List of contributors. Preface. 1. The subventricular zone: source of neuronal precursors for brain repair (A.Alvarez-Buylla, D.G. Herrera and H. Wichterle). 2. Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation (C.N. Svendsen and M.A. Caldwell). 3. Activity-dependent regulation of neuronal plasticity and self repair (G. Kempermann, H. van praag and F.H. Gage). 4. Immortalized neural cell lines for CNS transplantation (S.R. Whittemore and S.M. Onifer). 5. The chick/quail transplantation model to study central nervous system development (R.-M. Alvarado-Mallart). 6. Novel mechanisms in mammalian telencephalic development as revealed by neural transplantation ( K. Campbell and M. Olsson). 7. Reconstruction of cortical circuitry (M.A. Gates, R.A. Fricker and J.D. Macklis). 8. Xenotransplantation (E.B. Pedersen and H. Widner). 9. Encapsulated neural transplants (J.L. Tseng and P. Aebischer). 10. Improving the survival of grafted embryonic dopamine neurons in rodent models of Parkinson's disease (R.F. Castillo, O.Hansson and P. Brundin). 11. Transplantation in the rat model of Parkinson's disease: ectopic versus, homotopic graft placement (C. Winkler, D. Kirik, A. Björklund and S.B. Dunnett). 12. The primate model of Parkinson's disease: its usefulness, limitations, and importance in directing future studies (K.D. Bingaman and R.A.E. Bakay). 13. Clinical observations after neural transplantation in Parkinson's disease (O. Lindvall and P. Hagell). 14. Non-invasive in vivo imaging of transplant function (D.J. Brooks and P. Piccini). 15. Neurophatology of fetal nigra transplants for Parkinson's disease (J.H. Kordower and C.E. Sortwell). 16. The integration and function of striatal grafts (S.B. Dunnett, F. Nathwani and a. Björklund). 17. Striatal tissue transplantation in non-human primates (A.L. Kendall, P. Hantraye and S. Palfi). 18. Neural transplantation for the treatment of Huntington's disease (T.B. Freeman, R.A. Hauser, P.R. Sanberg and S. Saporta). 19. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? (J.H. Kordower, O. Isacson, L. Leventhal and D.F. Emerich). 20. Functional reconstruction of the hippocampus (R.M. Ridley, H.F. Baker and H. Hodges). 21. Restoration of function by neural transplantation in the ischemic brain (H. Nishino and C.V. Borlongan). 22. Functional aspects of cerebellar transplantation (L.C. Triarhou). 23. Preservation and restoration of vision following transplantation (P.J. Coffey, S.J.O. Whiteley and R.D. Lund). 24. Spinal cord motoneuron maintenance, injury and repair (T. Carlstedt and S. Cullheim). 25. Remyelination and restoration of axonal function by glial cell transplantation (S.-C. Zhang and I.D. Duncan). 26. The alleviation of pain by cell transplantation (I.D. Hentall and J. Sagen).