Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor SurfacesBy
- Ajit Sadana, Chemical Engineering Department, University of Mississippi, MS, USA
- Neeti Sadana, Jackson Memorial Hospital, The University of Miami, Miami, FL, USA
Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface.
The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc.
As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company.
This book is suitable for academic researchers, industrial researchers, military, homeland security, other governmental and private industries.
Hardbound, 372 Pages
Published: November 2007
- Preface1. Introduction2. Modeling and Theory 3. Biosensor Performance Parameters and their Enhancement 4. Fractal Analysis of Harmful Bacteria, Toxins, and Pathogen Detection on Biosensor Surfaces5. Fractal Binding and Dissociation Kinetics of Disease-Related Compounds on Biosensor Surfaces 6. Fractal Analysis of Binding and Dissociation of Analytes that Help Control Diseases on Biosensor Surfaces7. Fractal Analysis of Binding and Dissociation of Small Molecules Involved in Drug Discovery on Biosensor Surfaces8. Fractal Binding and Dissociation Kinetics of Prion-Related Interactions on Biosensor Surfaces9. Fractal Analysis of Binding and Dissociation of DNA-Analyte Interactions on Biosensor Surfaces10. Fractal Analysis of Binding and Dissociation of Protein-Analyte Interactions on Biosensor Surfaces 11. Fractal Analysis of Different Compounds Binding and Dissociation Kinetics on Biosensor Surfaces 12. Fractal Analysis Of Binding And Dissociation Kinetics of Environmental Contaminants and Explosives on Biosensor Surfaces 13. Market Size and Economics for Biosensors