Foundations of Regenerative Medicine

Preface
I. INTRODUCTION TO REGENERATIVE MEDICINE
Current and Future Perspectives of Regenerative medicine
Fundamentals of cell-based therapies
Stem Cell Research
II. BIOLOGIC AND MOLECULAR BASIS FOR REGENERATIVE MEDICINE
Molecular Organization of Cells
Cell-ECM interactions In Repair and Regeneration
Developmental Mechanisms of Regeneration
The molecular basis of pluripotency in Principles of Regenerative Medicine
III. CELLS AND TISSUE DEVELOPMENT
Embryonic Stem Cells: Derivation and Properties
Stem cells derived from amniotic fluid and placenta
Bone Marrow stem cells: Properties and Pluripotency
Mesenchymal Stem cells
Islet Cell Therapy and Pancreatic Stem Cells
Mechanical Determinants of Tissue Development
Morphogenesis and Morphogenic Proteins
Physical stress as a factor in tissue growth and remodeling
Engineering Cellular Microenvironments
Applications of Nanotechnology
IV. BIOMATERIALS FOR REGENERATIVE MEDICINE
Design Principles in Biomaterials and Scaffolds
Naturally Occurring Scaffold Materials
Synthetic Polymers
Surface Modification of Biomaterials
Biocompatibility and Bioresponse to biomaterials
V. THERAPEUTIC APPLICATIONS: Cell Therapy
Clinical islet transplantation
Cell Based Repair for Cardiovascular Regeneration and Neovascularization
Cell therapies for bone regeneration
Cell-Based Therapies for Musculoskeletal Repair
Hepatocyte Transplantation
Cell Based Drug Delivery
VI. THERAPEUTIC APPLICATIONS: Tissue Therapy
Engineering of Large Diameter Vessels
Cardiac Tissue
Intracorporeal Kidney Support
Genitourinary System
Tissue Engineering of the Reproductive System
Phalanges and Small Joints
Functional Tissue Engineering of Ligament and Tendon Injuries
Skeletal Muscle
Peripheral Nervous System
Innovative Regenerative Medicine Approaches to Skin Cell Based Therapy for Patients With Burn Injuries
VII. REGULATION AND ETHICS
Ethical Considerations
To Make Is to Know: The Ethical Issues in Human Tissue Engineering
Overview of FDA Regulatory Process
Current Issues in US Patent Law