Foundations of Regenerative Medicine book cover

Foundations of Regenerative Medicine

Clinical and Therapeutic Applications

The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today.

Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field.

Audience

researchers and technicians working in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, and bioengineering; bioengineering (mechanical & materials), cell biology, molecular biology, neurology, hematology, orthopedic, cancer, cardiology, ophthalmology, and physiology researchers, students, and practitioners

Hardbound, 824 Pages

Published: August 2009

Imprint: Academic Press

ISBN: 978-0-12-375085-3

Contents

  • Preface
    I. INTRODUCTION TO REGENERATIVE MEDICINE
    Current and Future Perspectives of Regenerative medicine
    Fundamentals of cell-based therapies
    Stem Cell Research
    II. BIOLOGIC AND MOLECULAR BASIS FOR REGENERATIVE MEDICINE
    Molecular Organization of Cells
    Cell-ECM interactions In Repair and Regeneration
    Developmental Mechanisms of Regeneration
    The molecular basis of pluripotency in Principles of Regenerative Medicine
    III. CELLS AND TISSUE DEVELOPMENT
    Embryonic Stem Cells: Derivation and Properties
    Stem cells derived from amniotic fluid and placenta
    Bone Marrow stem cells: Properties and Pluripotency
    Mesenchymal Stem cells
    Islet Cell Therapy and Pancreatic Stem Cells
    Mechanical Determinants of Tissue Development
    Morphogenesis and Morphogenic Proteins
    Physical stress as a factor in tissue growth and remodeling
    Engineering Cellular Microenvironments
    Applications of Nanotechnology
    IV. BIOMATERIALS FOR REGENERATIVE MEDICINE
    Design Principles in Biomaterials and Scaffolds
    Naturally Occurring Scaffold Materials
    Synthetic Polymers
    Surface Modification of Biomaterials
    Biocompatibility and Bioresponse to biomaterials
    V. THERAPEUTIC APPLICATIONS: Cell Therapy
    Clinical islet transplantation
    Cell Based Repair for Cardiovascular Regeneration and Neovascularization
    Cell therapies for bone regeneration
    Cell-Based Therapies for Musculoskeletal Repair
    Hepatocyte Transplantation
    Cell Based Drug Delivery
    VI. THERAPEUTIC APPLICATIONS: Tissue Therapy
    Engineering of Large Diameter Vessels
    Cardiac Tissue
    Intracorporeal Kidney Support
    Genitourinary System
    Tissue Engineering of the Reproductive System
    Phalanges and Small Joints
    Functional Tissue Engineering of Ligament and Tendon Injuries
    Skeletal Muscle
    Peripheral Nervous System
    Innovative Regenerative Medicine Approaches to Skin Cell Based Therapy for Patients With Burn Injuries
    VII. REGULATION AND ETHICS
    Ethical Considerations
    To Make Is to Know: The Ethical Issues in Human Tissue Engineering
    Overview of FDA Regulatory Process
    Current Issues in US Patent Law

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