Foundations of Regenerative Medicine

Clinical and Therapeutic Applications

Edited by

  • Anthony Atala, Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today.

Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field.

View full description

Audience

researchers and technicians working in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, and bioengineering; bioengineering (mechanical & materials), cell biology, molecular biology, neurology, hematology, orthopedic, cancer, cardiology, ophthalmology, and physiology researchers, students, and practitioners

 

Book information

  • Published: August 2009
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-375085-3


Table of Contents

Preface
I. INTRODUCTION TO REGENERATIVE MEDICINE
Current and Future Perspectives of Regenerative medicine
Fundamentals of cell-based therapies
Stem Cell Research
II. BIOLOGIC AND MOLECULAR BASIS FOR REGENERATIVE MEDICINE
Molecular Organization of Cells
Cell-ECM interactions In Repair and Regeneration
Developmental Mechanisms of Regeneration
The molecular basis of pluripotency in Principles of Regenerative Medicine
III. CELLS AND TISSUE DEVELOPMENT
Embryonic Stem Cells: Derivation and Properties
Stem cells derived from amniotic fluid and placenta
Bone Marrow stem cells: Properties and Pluripotency
Mesenchymal Stem cells
Islet Cell Therapy and Pancreatic Stem Cells
Mechanical Determinants of Tissue Development
Morphogenesis and Morphogenic Proteins
Physical stress as a factor in tissue growth and remodeling
Engineering Cellular Microenvironments
Applications of Nanotechnology
IV. BIOMATERIALS FOR REGENERATIVE MEDICINE
Design Principles in Biomaterials and Scaffolds
Naturally Occurring Scaffold Materials
Synthetic Polymers
Surface Modification of Biomaterials
Biocompatibility and Bioresponse to biomaterials
V. THERAPEUTIC APPLICATIONS: Cell Therapy
Clinical islet transplantation
Cell Based Repair for Cardiovascular Regeneration and Neovascularization
Cell therapies for bone regeneration
Cell-Based Therapies for Musculoskeletal Repair
Hepatocyte Transplantation
Cell Based Drug Delivery
VI. THERAPEUTIC APPLICATIONS: Tissue Therapy
Engineering of Large Diameter Vessels
Cardiac Tissue
Intracorporeal Kidney Support
Genitourinary System
Tissue Engineering of the Reproductive System
Phalanges and Small Joints
Functional Tissue Engineering of Ligament and Tendon Injuries
Skeletal Muscle
Peripheral Nervous System
Innovative Regenerative Medicine Approaches to Skin Cell Based Therapy for Patients With Burn Injuries
VII. REGULATION AND ETHICS
Ethical Considerations
To Make Is to Know: The Ethical Issues in Human Tissue Engineering
Overview of FDA Regulatory Process
Current Issues in US Patent Law