Folic Acid and Folates


  • Gerald Litwack, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
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Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.


Book information

  • Published: October 2008
  • ISBN: 978-0-12-374232-2

Table of Contents

1. Folate-Mediated One-Carbon MetabolismJennifer T. Fox and Patrick J. Stover2. Mathematical Models of Folate-Mediated One-Carbon Metabolism H. Frederik Nijhout, Michael C. Reed and C.M. Ulrich3. Folate Deprivation, the Methionine Cycle and Alzheimer¡¦s DiseaseFlaubert Tchantchou and Thomas B. Shea4. Benefits and Risks of Folic Acid Supplementation Young-In Kim5. Molecular Mechanisms of Adaptation to Folate DeficiencyIlan Ifergan and Yehuda G. Assaraf6. Structure and Function of the Reduced Folate Carrier: A Paradigm of a Major Facilitator Superfamily Mammalian Nutrient TransporterLarry H. Matherly and Zhanjun Hou 7. Renal Conservation of Folates: Role of Folate Transport ProteinsVijaya L. Damaraju, Carol E. Cass and Michael B. Sawyer8. Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory DiseaseChristopher P. Leamon and Ann L. Jackman9. Folate Receptor Expression in Pituitary Adenomas: Cellular and Molecular Analysis Chheng-Orn Evans, Congjun Yao, David Leborde and Nelson M. Oyesiku10. Regulation of Human Dihydrofolate Reductase Activity and ExpressionEmine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, Yi-Ching Hsieh11. Catalysis of Methyl Group Transfers Involving Tetrahydrofolate and B12Stephen W. Ragsdale12. Methyltetrahydrofolate in Folate-Binding Protein Glycine N-MethyltransferaseZigmund Luka13. Mechanism-Based Inhibitors of Folylpoly-ƒ×-glutamate Synthetase and ƒ×-Glutamyl Hydrolase: Control of Folylpoly-ƒ×-glutamate Homeostasis as a Drug TargetJames K. Coward and John J. McGuire14. Methylenetetrahydrofolate Reductase, Common Polymorphisms and Relation to DiseasePhilip Thomas and Michael Fenech15. Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase and Formyltetrahydrofolate SynthetasesKaren E. Christensen and Robert E. MacKenzie16. The Structure and Mechanism of 6-Hydroxymethyl-7,8-dihydropterin PyrophosphokinaseJeremy P. Derrick