Fibrous Proteins: Muscle and Molecular MotorsBy
- John Squire, Imperial College London, United Kingdom
- David Parry, Massey University, Palmerston North, New Zealand
Molecular Motors and Muscle is the second of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award-winning issue of Journal of Structural Biology. There are two major types of protein: Globular proteins which are often enzymes which speed up biochemical reactions and Fibrous proteins which often have more structural roles but can also have dynamic properties.Fibrous proteins are usually either elongated molecules which pack together to form long filaments, as in the case of the intermediate filaments in our hair and skin and as in collagen fibrils in tendons and bones or they are globular proteins which aggregate linearly to form long filaments, such as actin filaments or microtubules. Fibrous proteins act as molecular scaffolds in cells, they can be involved in transport of cell organelles or even on a visible scale as in our muscles. They provide the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. They are vital for life and represent a fascinating subset of the proteome. Advances in Protein Chemistry is available online on ScienceDirect full-text online of volumes 53 onwards.
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Cell biologists, Structural biologists, Biophysicists, Biochemists, Bioinformaticists, Medical pathologists, Physiologists, Anatomists, Geneticists.
Advances in Protein Chemistry and Structural Biology
Audio, 496 Pages
Published: August 2005
Imprint: Academic Press
- Chapter 1. Comparative Motile Mechanisms in Cells Chapter 2. Molecular Architecture in Muscle Contractile Assemblies Chapter 3. Titin and its associated proteins: the third myofilament system of the sarcomere Chapter 4. Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function Chapter 5. The Molecular Mechanism of Muscle Contraction Chapter 6. X-Ray Diffraction Studies of the Muscle and the Cross-bridge Cycle Chapter 7. Microtubules and MAPs Chapter 8. The structure of microtubule motor proteins Chapter 9. Rotary Molecular Motors Chapter 10. Cytoskeleton Dynamics Powers Nematode Sperm Motility Chapter 11. Structure and mechanism of DNA polymerases